ReviewMedComm2026
Neurocardiology: Brain-Heart Interactions in the Heart.
Review in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heart and brain maintain systemic homeostasis through continuous bidirectional communication mediated by neural regulation, biochemical signaling, and mechanical transduction. Disruption of this communication is increasingly recognized as a contributor to cardiovascular, neurological, cognitive, and psychological disorders. Growing evidence indicates that autonomic imbalance, neuroimmune activation, hemodynamic disturbances, inflammation, altered interoception, and brain network remodeling can mediate cross-organ injury between the heart and brain. These mechanisms underlie a spectrum of heart-brain comorbidities, but their shared pathways, disease-specific manifestations, and integrated management strategies remain insufficiently understood. In this review, we summarize the physiological basis of heart-brain interactions, focusing on neural, biochemical, and mechanical pathways. We then discuss six representative disorders: Takotsubo syndrome, epileptic heart, stroke-heart syndrome, heart failure, cardiac dementia, and psychocardiology. For each condition, we highlight key epidemiological features, pathophysiological mechanisms, and integrated heart-brain management strategies. We also review clinical trials targeting heart-brain interactions, including autonomic modulation, biomarker monitoring, neuroimaging assessment, exercise therapy, psychological intervention, and pharmacological therapy. By integrating basic mechanisms, clinical phenotypes, and translational advances, this review provides a systematic framework for understanding heart-brain comorbidities and advancing precision heart-brain medicine.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.