Evidence map›Paper›PMID 42699320›Full record

ArticleBioactive materials2027

Metabolic targeting by a small extracellular vesicle-based cellulose-GelMA hydrogel restores neurovascular regeneration in diabetic nerve injury.

Yihong Jiang, Zhaoxi Peng, Rui Zhang, Xiaoxue Chen, Sen Yang, Xiaoli Wang, Zhen Xu, Feng F Hong, Xinwu Lu, Kaichuang Ye and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yihong JiangDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhaoxi PengDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Rui ZhangDepartment of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoxue ChenDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Sen YangDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xiaoli WangDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhen XuYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, United States.
Feng F HongCollege of Biological Science and Medical Engineering, Donghua University, Shanghai, China.
Xinwu LuDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Kaichuang YeDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yun QianDepartment of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Luhan BaoDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xing ZhangDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic peripheral nerve injury (PNI-DM) causes severe sensory and motor dysfunction, yet the metabolic mechanisms impairing neurovascular repair remain unclear. Using histological and molecular analysis of human nerve and muscle tissues, we observed pronounced methylglyoxal-derived hydroimidazolone-1 (MG-H1)/methylglyoxal (MGO)-associated glycation stress, reduced expression of its detoxifying enzyme glyoxalase-1 (GLO-1), enhanced pyroptosis, disrupted neurovascular integrity, and distal muscle atrophy in PNI-DM patients compared with non-diabetic patients. These findings indicate a lesion-site association between PNI-DM and GLO-1/MGO metabolic imbalance. To develop a disease-oriented local intervention, we engineered adipose-derived stem cells to generate GLO-1-enriched small extracellular vesicles (G-sEVs) and incorporated them into a bacterial nanocellulose (BNC)-reinforced gelatin methacryloyl (GelMA) patch. The patch showed a stable nanofibrous architecture, excellent conformability, biocompatibility, and controlled release characteristics. In vitro and in vivo, G-sEV@BNC/GelMA mitigated MGO/MG-H1-associated carbonyl stress, reduced inflammation and pyroptosis, promoted neurovascular regeneration, and preserved neuromuscular integrity in diabetic rats. These findings support G-sEV@BNC/GelMA as a disease-context-specific perineural delivery strategy that couples MGO-related metabolic regulation with multicellular neurovascular repair in PNI-DM.

Indexed as

Bacterial nanocelluloseDiabetic peripheral nerve injuryGlyoxalase-1MethylglyoxalSmall extracellular vesicles

Identifiers

PMID42699320
PMCPMC13543094

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.