ArticleJournal of mass spectrometry : JMS2026
LC-MS/MS-Based Lipidomic Profiling Reveals the Regulatory Effect of Stemoninoamide on TGF-β1-Induced Myofibroblast Transition in HFL1 Cells.
Article in Journal of mass spectrometry : JMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
The dried roots of Stemona tuberosa, known as "Bai-Bu" in traditional Chinese medicine, have been employed as a therapeutic agent for the treatment of pertussis and tuberculosis. The chemical composition of S. tuberosa is dominated by alkaloids which have been reported to possess antifibrosis effect. Herein, ELISA kit and immunofluorescence analyses showed that the alkaloid of stemoninoamide (Stem) isolated from S. tuberosa exhibited inhibitory effect on the production of α-SMA and Col-1 of HFL1 cells stimulated by TGF-β1. Further lipidomic analysis based on LC-MS/MS revealed differential metabolites via multivariate statistical analysis. Pathway enrichment analyses indicated that differential metabolites were mostly implicated in S1P/S1PR signaling pathway, which could be potentially associated with the antifibrosis mechanism of Stem.
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