Evidence map›Paper›PMID 42701751›Full record

ArticleBioinformation2026

Comparative evaluation of hrHPV DNA testing, cervical cytology and histopathology for cervical precancer detection.

Atul Jain, Mamta Meena, Shiny Vincent, Iqra Sheikh, Surabhi Sharma, Kuldeep Singh, Rajdeep Paul

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Atul JainDepartment of Pathology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India.
Mamta MeenaDepartment of Microbiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
Shiny VincentDepartment of Medical Laboratory, Leonard Hospital, Tamil Nadu, India.
Iqra SheikhDepartment of Clinical Pathology, Lok Nayak Hospital, New Delhi, India.
Surabhi SharmaDepartment of Microbiology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India.
Kuldeep SinghDepartment of Microbiology, Chirayu Medical College & Hospital, Bhopal, Madhya Pradesh, India.
Rajdeep PaulDepartment of Microbiology, Chirayu Medical College & Hospital, Bhopal, Madhya Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer remains a major public health challenge in India, driven primarily by persistent high-risk HPV infection. Hence, this prospective study evaluated hrHPV DNA testing, cervical cytology and co-testing in 400 symptomatic women, using histopathology as the gold standard for CIN2+ detection. HPV DNA testing showed the highest sensitivity (90%) and diagnostic accuracy (63.8%) compared with cytology and co-testing, while ROC analysis confirmed its superior performance (AUC 0.75). HPV16 was the predominant genotype, followed by HPV18, HPV52 and HPV58, together accounting for most high-grade lesions. Thus, we show HPV DNA testing as a more reliable primary screening method than cytology in resource-limited settings.

Indexed as

Cervical cancercytologygenotypinghistopathologyhrHPV DNA testingscreening

Identifiers

PMID42701751
PMCPMC13545909

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.