Evidence map›Paper›PMID 42703339›Full record

ArticleJournal of gastrointestinal oncology2026

Sphingosine-1-phosphate induces angiogenesis via the activating STAT3 signaling pathway to drive colorectal cancer progression.

Qianlong Ling, Qidong Chen, Ruipeng Wang, Wenjiang Man, Liang Yan, Bowen Han, Zhongxu Yuan

Abstract read
In one paragraph

Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qianlong LingGraduate School of Bengbu Medical University, Bengbu, China.
Qidong ChenGraduate School of Bengbu Medical University, Bengbu, China.
Ruipeng WangGraduate School of Bengbu Medical University, Bengbu, China.
Wenjiang ManDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Liang YanDepartment of General Surgery, Anhui No. 2 Provincial People's Hospital, Hefei, China.
Bowen HanDepartment of General Surgery, Anhui No. 2 Provincial People's Hospital, Hefei, China.
Zhongxu YuanDepartment of General Surgery, Anhui No. 2 Provincial People's Hospital, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tumor angiogenesis is a characteristic hallmark of carcinogenesis. Sphingosine-1-phosphate (S1P), a key bioactive lipid produced Methods: Results: Conclusions: S1P facilitates the emergence of malignant phenotypes of CRC cells, the angiogenesis of HUVECs

Indexed as

angiogenesisColorectal cancer (CRC)sphingosine-1-phosphate (S1P)STAT3tumor progression

Identifiers

PMID42703339
PMCPMC13546571

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.