ArticleJournal of gastrointestinal oncology2026
Histopathological subtypes independently predict survival in ampullary carcinoma: a contemporary SEER nomogram study.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Ampullary adenocarcinoma (AAC) has distinct histopathological subtypes impacting prognosis, yet American Joint Committee on Cancer (AJCC) staging overlooks this distinction. Few large-scale studies have evaluated cancer-specific survival (CSS) or integrated subtypes into prognostic nomograms. This study aimed to evaluate the prognostic impact of histopathological subtypes on CSS in AAC patients and to develop a validated nomogram incorporating subtype for individualized risk stratification. Methods: Patients diagnosed between 2004-2021 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. CSS was compared using Kaplan-Meier and Cox models. A nomogram incorporating histopathological subtype was developed and validated using C-index, receiver operating characteristic (ROC) curves, and decision curve analysis. Results: Among 726 patients, 385 (53.0%) had intestinal type and 341 (47.0%) had pancreatobiliary/mixed type. Pancreatobiliary/mixed subtypes showed significantly worse CSS [median: 39 Conclusions: Histopathological subtype independently predicts CSS in ampullary carcinoma. This subtype-inclusive nomogram outperforms conventional staging for individualized prediction, supporting precision oncology approaches.
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