Evidence map›Paper›PMID 42704362›Full record

ArticleCell biochemistry and function2026

S100 Calcium-Binding Protein 16 (S100A16) Promotes Hepatic Stellate Cell Activation Via Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2)-mediated Glycolysis to Facilitate Liver Fibrosis.

Shiyu Ou, Xiaoling Tang, Juan Liu, Rong Ouyang, Shijiang Huang, Shuwen Weng, Jinping Qin, Dingheng Liang, Ling Du, Zhongzhuan Li

Abstract read
In one paragraph

Article in Cell biochemistry and function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shiyu OuDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.ORCID https://orcid.org/0000-0002-3161-7594
Xiaoling TangDepartment of Pharmacy, Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou, P. R. China.
Juan LiuDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.
Rong OuyangDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.
Shijiang HuangDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.
Shuwen WengDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.
Jinping QinDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.
Dingheng LiangDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.
Ling DuDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.ORCID https://orcid.org/0009-0000-0648-6767
Zhongzhuan LiDepartment of Gastroenterology, Liuzhou Workers' Hospital (The Fourth Affiliated Hospital of Guangxi Medical University), Liuzhou, P. R. China.ORCID https://orcid.org/0009-0005-0501-9231

Funding

Planned projects of the Liuzhou Science and Technology Bureau 2024YB0101A01platform of Guangxi Key Health‑care Discipline (Gastroenterology)Project of Guangxi administration of traditional Chinese medicine GXZYB20220434Research Project of Guangxi Zhuang Autonomous Region Health Commission Z20211018Research Project of Guangxi Zhuang Autonomous Region Health Commission Z-B20261565Youth Science Foundation of Guangxi Medical University GXMUYSF202348
6 · The paper itself

Abstract

Hepatic stellate cell (HSC) activation is a key mediator in hepatic fibrosis, with glycolysis serving a key regulatory function. S100 calcium-binding protein 16 (S100A16) has been associated with various pathologies; however, its function and underlying mechanisms in liver fibrosis remains elusive. This study aimed to elucidate the functional role of S100A16 in HSC activation and its interaction with Erb-B2 receptor tyrosine kinase 2 (ERBB2)-mediated glycolysis. Transforming growth factor-β1 (TGF-β1)-stimulated human liver stellate cells (LX2) and carbon tetrachloride (CCl

Indexed as

Erb-b2 Receptor Tyrosine KinasesGlycolysisHepatic Stellate CellsLiver CirrhosisS100 ProteinsAnimalsCarbon TetrachlorideCell LineCell ProliferationCells, CulturedHumansMaleMiceMice, Inbred C57BLTransforming Growth Factor beta1Carbon TetrachlorideERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesS100 ProteinsTransforming Growth Factor beta1ERBB2glycolysishepatic stellate cell activationliver fibrosisS100A16

Identifiers

PMID42704362
PMCPMC13549247

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.