Evidence map›Paper›PMID 42704498›Full record

ArticleMikrochimica acta2026

Ultrasmall Ag₂Se@Mn quantum dots enable dual-modal imaging-guided early detection and antioxidant therapy of acute kidney injury.

Yun Qu, Yiping Gu, Qinzhi Zeng, Xianbin Ma, Chao Li, Yao Lei, Hai-Yan Xie, Ran Cui

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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yun QuSchool of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Yiping GuThe Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, School of Public Health, Guilin Medical University, Guilin, 541199, Guangxi, China.
Qinzhi ZengCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Xianbin MaSchool of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China.
Chao LiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Yao LeiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Hai-Yan XieChemical Biology Center, Peking University, Beijing, 100191, China. hyanxie@bjmu.edu.cn.ORCID https://orcid.org/0009-0008-8208-7168
Ran CuiCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China. cuiran@whu.edu.cn.

Funding

Beijing Institute of Technology Research Fund Program for Young Scholars XSQD-202212002Beijing Natural Science Foundation L242109National Natural Science Foundation of China 22293034, 22293030, and 32101140National Science Fund for Distinguished Young Scholars 22025401Natural Science Foundation of Shandong Province ZR2024QC324
6 · The paper itself

Abstract

Acute kidney injury (AKI) is a serious clinical condition with high morbidity and mortality, yet early detection and effective treatment remain challenging. Herein, we developed ultrasmall quantum dots (QDs) for dual-modal imaging-guided early detection and antioxidant therapy of AKI. Benefiting from the ultrasmall hydrodynamic size, the as‑prepared Ag₂Se@Mn QDs exhibit favorable renal clearance and prolonged retention in injured kidneys. The QDs possess concentration-dependent T1-weighted magnetic resonance imaging (MRI) contrast and near-infrared fluorescence properties, enabling real-time, non-invasive visualization of cisplatin-induced AKI progression. Especially, MRI revealed renal dysfunction up to 66 h earlier than conventional clinical indicators, providing a critical window for early intervention. Furthermore, the inherent ROS-scavenging activity of Mn²⁺ endows QDs with potent antioxidant capacity by efficiently eliminating hydroxyl radicals (·OH) and superoxide anions (O₂

Indexed as

Acute Kidney InjuryAntioxidantsManganeseQuantum DotsAnimalsCisplatinContrast MediaHumansMagnetic Resonance ImagingMaleOptical ImagingSeleniumSilverAntioxidantsCisplatinContrast MediaManganeseSeleniumSilverAcute kidney injuryFluorescence imagingMagnetic resonance imagingQuantum dotsROS scavenging

Identifiers

PMID42704498

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.