ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2026
Early-life GABA-A receptor blockade with bicuculline attenuates anxiety-like behaviors and cognitive deficits induced by 24-hr sleep deprivation in adult male rats.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly postnatal GABAergic signaling is crucial for brain development and circuit formation. While Gamma-aminobutyric acid (GABA) regulates sleep-wake cycles, sleep deprivation causes cognitive impairment and oxidative stress. Although blocking GABA-A receptors has been shown to improve cognition, the effect of such blockade during development on sleep-loss-induced cognitive deficits remains unknown.
objectivesAccordingly, this study was designed to investigate the effects of early-life inhibition of GABA-A receptors on sleep deprivation-induced cognitive impairments in adulthood.
methodsThirty-two male neonatal rats were randomly assigned to four equal-sized groups (n = 8/group): Control, Bicuculline (300 µg/kg subcutaneously on postnatal days 7, 9, and 11), Sleep Deprivation (24-h SD at postnatal days (PNDs) 60-70), and Bicuculline + SD. In young adulthood (PNDs 60-70), anxiety-like behavior was assessed using the Elevated plus maze (EPM), while the Morris water maze (MWM) was used to evaluate spatial learning and memory. We then measured superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, as well as malondialdehyde (MDA) levels in hippocampal tissue.
resultsSD alone significantly increased anxiety-like behaviors, impaired spatial learning and short-term memory, reduced hippocampal SOD and GPx activities, and elevated MDA. Remarkably, early-life bicuculline pretreatment prevented SD-induced cognitive deficits, attenuated anxiety-like responses, and restored antioxidant enzyme activities while normalizing MDA levels.
conclusionEarly postnatal transient blockade of GABA-A receptors was associated with decreased vulnerability to cognitive deficits, anxiety-like behaviors, and oxidative stress induced by acute sleep deprivation in adulthood. This reveals a novel developmental role of early GABAergic signaling in defense against sleep loss-induced neuropsychiatric and cognitive deficits.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.