Evidence map›Paper›PMID 42706166›Full record

ReviewZhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi2026

[Research advances in mesenchymal stem cell therapy for graft-versus-host disease].

W H Wang, X L Pei, J Y Luo, E L Jiang

Abstract readReviewEnglish Abstract
In one paragraph

Review in Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

W H WangHaihe Laboratory of Cell Ecosystem, Tianjin Medical University, Tianjin 300070, China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.
X L PeiState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.
J Y LuoState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.
E L JiangState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graft-versus-host disease (GVHD) remains a severe complication after allogeneic hematopoietic stem cell transplantation, and effective treatment options remain limited, particularly for patients with steroid-refractory GVHD or failure of multiple lines of therapy. Mesenchymal stem cell (MSC) therapy has shown promise for the prevention and treatment of GVHD because of the low immunogenicity and immunomodulatory, anti-inflammatory, and tissue-reparative properties of MSC. To date, MSC-based products have been approved for the treatment of acute GVHD (aGVHD) in several countries, including China. Although MSC therapy is generally well tolerated, its broader clinical application remains challenged by substantial interindividual variability in therapeutic response, potential safety concerns, and the lack of harmonized standards for manufacturing and quality control. This review systematically summarizes recent clinical research on MSC-based interventions for GVHD and critically discusses their therapeutic prospects and current limitations, with the aim of informing standardized and precision-oriented clinical application of MSC therapy.

Indexed as

Graft vs Host DiseaseMesenchymal Stem Cell TransplantationHematopoietic Stem Cell TransplantationHumansMesenchymal Stem Cells

Identifiers

PMID42706166
PMCPMC13575534

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.