Evidence map›Paper›PMID 42707169›Full record

ArticleFrontiers in medicine2026

High-intensity focused ultrasound combined with syndrome differentiation-based individualized herbal therapy and 12-month outcomes in patients with adenomyosis: a prospective non-randomized study.

Cuiling Zhang, Lijun Zhang, Shuping Zhao, Yanyan Huang, Liangqian Zhao, Rongxing Wang, Yuling Wang, Deyan Sun, Yongsheng Ma, Qiuling Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cuiling ZhangState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
Lijun ZhangState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
Shuping ZhaoState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
Yanyan HuangDepartment of Neurosurgery and Glioma Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Liangqian ZhaoDepartment of Gynecology, Linyi Hospital of Traditional Chinese Medicine, Linyi, Shandong, China.
Rongxing WangDepartment of Gynecology, Linyi Hospital of Traditional Chinese Medicine, Linyi, Shandong, China.
Yuling WangDepartment of Gynecology, Linyi Hospital of Traditional Chinese Medicine, Linyi, Shandong, China.
Deyan SunDepartment of Pharmacy, Linyi Hospital of Traditional Chinese Medicine, Linyi, Shandong, China.
Yongsheng MaDepartment of Traditional Chinese Medicine, Linyi Hospital of Traditional Chinese Medicine, Linyi, Shandong, China.
Qiuling ShiState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the association of high-intensity focused ultrasound (HIFU) combined with syndrome differentiation-based individualized traditional Chinese medicine (TCM) herbal therapy with 12-month clinical outcomes compared with HIFU monotherapy in patients with adenomyosis (AM). Methods: This prospective non-randomized, patient-preference, parallel-controlled study enrolled 88 patients with adenomyosis between November 2021 and November 2023; 87 completed 12-month follow-up and were analyzed (HIFU, Results: At 1 month, the adjusted between-group NRS difference was not significant ( Conclusion: In this prospective non-randomized study, HIFU combined with syndrome differentiation-based individualized TCM herbal therapy was associated with greater improvement in dysmenorrhoea and greater reductions in uterine and lesion volumes over 12 months than HIFU alone, but not with lower symptom recurrence. These preliminary associations require confirmation in adequately powered randomized controlled trials.

Indexed as

adenomyosisdysmenorrhoeahigh intensity focused ultrasoundTCMtraditional Chinese medicine

Identifiers

PMID42707169
PMCPMC13547264

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.