Evidence map›Paper›PMID 42707784›Full record

ArticleStroke (Hoboken, N.J.)2026

Real-World Safety and Efficacy of Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Retrospective Cohort Study of 38 049 Patients.

Ariel Sacknovitz, Isaac B Thorman, Dinusha Wanniarachchige, Eris Spirollari, Ankita Jain, Michael C Schubert, Sauson Soldozy, Ilya Frid, Gurmeen Kaur, Stephan A Mayer and 2 more

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In one paragraph

Article in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ariel SacknovitzSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).ORCID https://orcid.org/0009-0008-6236-1190
Isaac B ThormanSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).ORCID https://orcid.org/0009-0003-6296-3793
Dinusha WanniarachchigeSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).
Eris SpirollariSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).
Ankita JainSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).ORCID https://orcid.org/0009-0002-4761-7828
Michael C SchubertDepartment of Otolaryngology-Head and Neck Surgery (I.B.T., M.C.S.), Johns Hopkins University, Baltimore, MD.ORCID https://orcid.org/0000-0002-5975-374X
Sauson SoldozyDepartment of Neurosurgery (A.S., E.S., A.J., S.S., I.F., G.K., S.A.M., C.D.G., F.A.-M.), Westchester Medical Center, Valhalla, NY.
Ilya FridDepartment of Neurosurgery (A.S., E.S., A.J., S.S., I.F., G.K., S.A.M., C.D.G., F.A.-M.), Westchester Medical Center, Valhalla, NY.
Gurmeen KaurSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).ORCID https://orcid.org/0000-0002-4732-8834
Stephan A MayerSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).ORCID https://orcid.org/0000-0002-1272-6277
Chirag D GandhiSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).ORCID https://orcid.org/0000-0002-8423-0414
Fawaz Al-MuftiSchool of Medicine, New York Medical College, Valhalla (A.S., I.B.T., D.W., E.S., A.J., G.K., S.A.M., C.D.G., F.A.-M.).ORCID https://orcid.org/0000-0003-4461-7005

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic subdural hematoma is a complex but commonly treated neurosurgical condition, particularly affecting the elderly. Traditional treatment involves open surgeries, but middle meningeal artery embolization (MMAE) has emerged as an effective, minimally invasive adjunctive. The objective of this study is to assess the safety and efficacy of MMAE in combination with surgery using real-world data.

methodsThis retrospective cohort study analyzed data from the TriNetX Research Network. Outcomes of mortality, reoperation, and hospital readmission were studied using Cox proportional hazard models controlling for age, sex, indications of severity, type of surgical intervention, antiplatelet/anticoagulant use, comorbidities, and hospitalization events. Patients were followed for up to 6 years.

resultsThis study included 38 049 patients with chronic subdural hematoma, of which 486 received surgery with MMAE and 5362 received surgery monotherapy. At 90 days after surgery, mortality was 5.2% in the MMAE group and 7.7% in the surgery monotherapy group (

conclusionsAmong patients with chronic subdural hematoma who received surgery, patients receiving adjunctive MMAE experienced lower mortality rates out to 6 years of follow-up, but the difference was not significant after full adjustment. Beginning 1 year after surgery, patients receiving combination therapy had significantly lower long-term rehospitalization compared with patients receiving surgery monotherapy. Future prospective studies will help identify strengths and weaknesses of this highly promising treatment modality.

Indexed as

agedanticoagulantshematoma, subdural, chronichospitalizationmeningeal arteries

Identifiers

PMID42707784
PMCPMC13549506

What Socratic holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.