Evidence map›Paper›PMID 42707800›Full record

ArticleStroke (Hoboken, N.J.)2026

Radial Versus Femoral Access for Carotid Artery Stenting in Patients With Carotid Artery Stenosis: Protocol of the Multicenter RACE-CAS Randomized Trial.

Rui Liu, Kang Yuan, Xuehan Liu, Wen Sun, Xianjun Huang, Hao Wang, Tingyu Yi, Xin Liu, Qin Yin, Ruidong Ye and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05416853 (Radial Versus Femoral Access For Carotid Artery Stenting In Patients With Carotid-Artery Stenosis ：a Prospective, Randomized, Multicenter, Noninferiority Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05416853 nacompletednot on this map

Radial Versus Femoral Access For Carotid Artery Stenting In Patients With Carotid-Artery Stenosis ：a Prospective, Randomized, Multicenter, Noninferiority Trial

TypeinterventionalSponsorThe First Affiliated Hospital of University of Science and Technology of ChinaRan2022 to 2026Enrolled1,200ConditionsIschemic Stroke, Carotid Stenosis, Cerebral Revascularization, Carotid Artery DiseasesArmsCarotid Artery Stenting (CAS)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rui LiuDivision of Life Sciences and Medicine, Department of Neurology, The First Affiliated Hospital of University of Science and Technology of China (USTC), USTC, Hefei (R.L., Xuehan Liu, W.S., Xinfeng Liu).ORCID https://orcid.org/0000-0002-3504-368X
Kang YuanDepartment of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, China (R.L., K.Y., Q.Y., R.Y., M.M., W.Z., Xinfeng Liu).ORCID https://orcid.org/0000-0002-4482-2503
Xuehan LiuDivision of Life Sciences and Medicine, Department of Neurology, The First Affiliated Hospital of University of Science and Technology of China (USTC), USTC, Hefei (R.L., Xuehan Liu, W.S., Xinfeng Liu).
Wen SunDivision of Life Sciences and Medicine, Department of Neurology, The First Affiliated Hospital of University of Science and Technology of China (USTC), USTC, Hefei (R.L., Xuehan Liu, W.S., Xinfeng Liu).ORCID https://orcid.org/0000-0002-7268-2085
Xianjun HuangDepartment of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China (X.H.).ORCID https://orcid.org/0000-0003-2646-982X
Hao WangDepartment of Neurology, Linyi People's Hospital, Affiliated Hospital of Shandong Second Medical University, Shandong Provincial Clinical Research Center for Geriatric Diseases, China (H.W.).ORCID https://orcid.org/0000-0002-1686-5899
Tingyu YiDepartment of Neurointervention, Zhangzhou Municipal Hospital, Fujian Medical University, China (T.Y.).ORCID https://orcid.org/0000-0003-3110-5844
Xin LiuDepartment of Neurology, Zoucheng People's Hospital, China (Xin Liu).
Qin YinDepartment of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, China (R.L., K.Y., Q.Y., R.Y., M.M., W.Z., Xinfeng Liu).
Ruidong YeDepartment of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, China (R.L., K.Y., Q.Y., R.Y., M.M., W.Z., Xinfeng Liu).ORCID https://orcid.org/0000-0003-0490-7331
Minmin MaDepartment of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, China (R.L., K.Y., Q.Y., R.Y., M.M., W.Z., Xinfeng Liu).
Wusheng ZhuDepartment of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, China (R.L., K.Y., Q.Y., R.Y., M.M., W.Z., Xinfeng Liu).ORCID https://orcid.org/0000-0003-0668-5832
Xinfeng LiuDivision of Life Sciences and Medicine, Department of Neurology, The First Affiliated Hospital of University of Science and Technology of China (USTC), USTC, Hefei (R.L., Xuehan Liu, W.S., Xinfeng Liu).ORCID https://orcid.org/0000-0002-8182-9632

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarotid artery stenting (CAS) is conventionally performed via transfemoral access (TFA), which requires prolonged postoperative immobilization and is associated with access-site complications. Transradial access (TRA) has emerged as an alternative to TFA for suitable vessel caliber and improved patient comfort. However, high-quality evidence directly comparing TRA and TFA for CAS in patients with carotid artery stenosis is still lacking. This trial aims to determine whether TRA is noninferior to TFA in patients treated with CAS due to carotid artery stenosis.

methodsThe RACE-CAS (Radial Versus Femoral Access for Carotid Artery Stenting in Patients With Carotid-Artery Stenosis) is a prospective, randomized, open-label, blinded-end point, multicenter trial. Up to 3000 patients with carotid artery stenosis will be randomly assigned in a 1:1 ratio to receive CAS treatment via either TRA or TFA across 70 centers in China.

resultsThe primary end point is the incidence of death, new-onset stroke, myocardial infarction, or severe hemorrhage events within 30 days post-procedure, analyzed in the full analysis set using risk differences with 2-sided 95% CIs for noninferiority testing. Key secondary outcomes include the successful rate of CAS and angiography, patient comfort, and each individual component of the primary end point within 48 hours or 30 days post-procedure. Safety outcomes include all adverse events and severe adverse events. The RACE-CAS trial enrolled its first patient on July 3, 2022, and recruitment is ongoing. At the time of manuscript submission, the sample size required for the first planned interim analysis had been completed.

conclusionsThe RACE-CAS trial will provide definitive, high-level evidence on the comparative efficacy and safety of TRA versus TFA for carotid artery stenting in patients with carotid artery stenosis, with the goal of guiding clinical practice. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05416853.

Indexed as

cardiovascular diseasescarotid stenosisendarterectomy, carotidischemic strokeradial artery

Identifiers

PMID42707800
PMCPMC13549542

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.