ArticleFrontiers in nutrition2026
Associations of the Zhejiang University (ZJU) index with reproductive outcomes in women with polyendocrine metabolic ovarian syndrome: a
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The Zhejiang University (ZJU) index is a novel composite metabolic score incorporating body mass index, fasting glucose, triglycerides, and the alanine aminotransferase/aspartate aminotransferase ratio. This study aimed to evaluate whether baseline ZJU index is associated with reproductive outcomes in women with polyendocrine metabolic ovarian syndrome (PMOS) undergoing fertility treatment. Methods: This Results: Women in the highest ZJU tertile had significantly lower rates of ovulation, conception, clinical pregnancy, and live birth compared with the lowest tertile (all P < 0.05). In the primary adjusted model (Model 2), each one-unit increase in ZJU was associated with reduced odds of ovulation (OR 0.94, 95% CI 0.91-0.97), conception (OR 0.96, 95% CI 0.93-0.99), clinical pregnancy (OR 0.95, 95% CI 0.92-0.98), and live birth (OR 0.95, 95% CI 0.92-0.99). No significant non-linearity was observed (all Conclusion: A higher baseline ZJU index was associated with poorer reproductive outcomes in women with PMOS undergoing fertility treatment. The ZJU index may serve as a metabolic marker associated with reproductive outcomes in women with PMOS. However, its ability to predict individual reproductive outcomes and any clinically applicable threshold require further evaluation in dedicated prediction studies with external validation.
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