ArticleFrontiers in toxicology2026
Sex-specific cardiac remodeling and metabolic reprogramming in IUGR F2 fetuses following glyphosate or glyphosate-based herbicide exposure.
Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We previously demonstrated that perinatal exposure to a glyphosate-based herbicide (GBH) or pure glyphosate (Gly) induces intrauterine growth restriction (IUGR) in second-generation (F2) rats. Given the association between IUGR and fetal cardiac remodeling, we investigated whether ancestral exposure programs structural, mitochondrial, and metabolic alterations in F2 fetal hearts. Pregnant F0 rats received GBH or Gly (3.88 and 3.83 mg glyphosate/kg/day, respectively) from gestational day (GD) 9 to F1 weaning. F1 females were subsequently mated and euthanized at GD19 to collect male and female F2 fetal hearts. Both treatments increased relative heart weight in males, while GBH induced left ventricle dilation in both sexes, compatible with a globular phenotype. In males, Gly reduced cardiomyocyte proliferation and
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