Evidence map›Paper›PMID 42708477›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Are infraslow oscillations the missing link between sleep and Alzheimer's?

Demetrio Grollero, Victoria Gabb, Jonathan Blackman, Amanda Heslegrave, Luisa de Vivo, Elizabeth Coulthard, Michele Bellesi

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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Demetrio GrolleroDepartment of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Victoria GabbBristol Medical School, University of Bristol, Bristol, UK.
Jonathan BlackmanBristol Medical School, University of Bristol, Bristol, UK.
Amanda HeslegraveDepartment of Neurodegenerative Diseases, University College London, London, UK.
Luisa de VivoSchool of Pharmacy, University of Camerino, Camerino, Italy.
Elizabeth CoulthardBristol Medical School, University of Bristol, Bristol, UK.
Michele BellesiCenter for Neuroscience, University of Camerino, Camerino, Italy.

Funding

Above and BeyondAlzheimer's Research United KingdomBRACEBristol and Weston Hospitals CharityDavid Telling Charitable TrustGiovanni Armenise-Harvard FoundationNIHR Bristol Biomedical Research CentrePhilanthropic donations from S Scobie and A Graham
6 · The paper itself

Abstract

introductionLocus coeruleus (LC) and glymphatic dysfunction have been linked both to Alzheimer's disease (AD) and, recently, to infraslow oscillation (ISO) in sleep spindle (sigma) activity (ISO). Here we hypothesize ISO integrity is a critical link between sleep and AD.

methodsWe analyzed non-rapid eye movement sleep electroencephalogram (EEG) data from AD participants and controls, extracting ISO peak amplitude, intrinsic frequency, and bandwidth from the sigma-power time-course. We assessed group differences and correlations with plasma biomarkers (Aβ42/40, pTau181, pTau217, neurofilament light chain [NfL], glial fibrillary acidic protein [GFAP]).

resultsISO peak amplitude was significantly reduced in AD, while intrinsic frequency and bandwidth were preserved. ISO peak amplitude showed a trend-level association with Aβ42/40, whereas ISO bandwidth was positively associated with NfL, and showed trends with GFAP and lower verbal memory retention. DISCUSSION: Selective weakening of ISO in AD is consistent with LC dysfunction and impaired glymphatic cycling. ISO may be a novel mechanism and electrophysiological marker linking sleep microarchitecture to AD pathology.

Indexed as

Alzheimer DiseaseSleepAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersElectroencephalographyFemaleGlial Fibrillary Acidic ProteinHumansLocus CoeruleusMaletau ProteinsAmyloid beta-PeptidesBiomarkersGlial Fibrillary Acidic Proteintau ProteinsAlzheimer's diseaseEEG biomarkersglymphatic systeminfraslow oscillationslocus coeruleussleep spindles

Identifiers

PMID42708477
PMCPMC13551593

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.