Evidence map›Paper›PMID 42709232›Full record

ArticleEuropean journal of nutrition2026

Gastrointestinal digestion enhances the release of bioactive peptides from yogurt.

Christoper Caesar Yudho Sutopo, Wei-Ting Hung, Awang Tri Satria, Hariadi Darmawan, David Yudianto, Jue-Liang Hsu

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Article in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christoper Caesar Yudho Sutopo *Department of Animal Science and Technology, National Taiwan University, Taipei, 106037, Taiwan.
Wei-Ting Hung *Institute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
Awang Tri SatriaFaculty of Animal Science and Technology, Universitas Brawijaya, Malang, 65145, Indonesia.
Hariadi DarmawanDepartment of Animal Science, PSDKU Universitas Brawijaya Kediri, Kediri, 64111, Indonesia.
David YudiantoQuality Assurance of Food Industry, Politeknik AKA Bogor, Bogor, 16154, Indonesia.
Jue-Liang HsuDepartment of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan. jlhsu@mail.npust.edu.tw.

Funding

National Science and Technology Council NSTC 114-2637-M-020-001
6 · The paper itself

Abstract

purposeThis study investigated whether simulated gastrointestinal (SGI) digestion enhances the release of bioactive peptides from yogurt and improves their associated bioactivities.

methodsYogurt was subjected to INFOGEST-based SGI digestion. Bioactivities were evaluated using ACE and DPP-IV inhibition and DPPH radical scavenging assays. Protein degradation was assessed by SDS-PAGE, and peptides were identified by UPLC-LTQ Orbitrap mass spectrometry, followed by in silico peptide screening and molecular docking.

resultsCompared with undigested yogurt, SGI digestion markedly enhanced ACE inhibitory, DPP-IV inhibitory, and antioxidant activities, with IC

conclusionSGI digestion promotes the release of low-molecular-weight peptides with enhanced in vitro bioactivities, providing a peptide-level framework for prioritizing yogurt-derived peptide candidates for future validation. Further experimental validation is needed before functional food, nutraceutical, or therapeutic applications can be proposed.

Indexed as

Bioactive Peptides, DietaryDigestionGastrointestinal TractPeptidesYogurtAngiotensin-Converting Enzyme InhibitorsAntioxidantsDipeptidyl-Peptidase IV InhibitorsHumansMolecular Docking SimulationAngiotensin-Converting Enzyme InhibitorsAntioxidantsBioactive Peptides, DietaryDipeptidyl-Peptidase IV InhibitorsPeptidesACE inhibitionBioactive peptidesDPP-IV inhibitionMolecular dockingPeptidomicsSimulated gastrointestinal digestion

Identifiers

PMID42709232

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.