ReviewMolecular biology reports2026
Macrophage heterogeneity in organ fibrosis in the era of single-cell omics.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Organ fibrosis is the ultimate common pathway resulting from dysregulated tissue repair caused by chronic inflammation, it accounts for approximately 45% of global mortality, and there are currently no effective clinical treatments to reverse it. As the central immune cells in the fibrotic microenvironment, macrophages exhibit a high degree of phenotypic and functional heterogeneity that far exceeds the traditional M1/M2 dichotomy. Based on the latest evidence from single-cell transcriptomics and spatial transcriptomics, this review establishes a multidimensional framework for macrophage heterogeneity that encompasses cellular origin, disease stage, spatial microenvironment, and functional output. We compared the conserved and organ-specific characteristics of macrophage subsets in pulmonary, hepatic, renal, and cardiac fibrosis, highlighting that Secreted Phosphoprotein 1
Indexed as
Identifiers
42709259What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.