Evidence map›Paper›PMID 42709265›Full record

ArticleJournal of bioenergetics and biomembranes2026

BICC1 attenuates oxidative stress-induced osteogenic injury via regulation of the PDK/PDH axis in MC3T3-E1 cells.

Zhongshuang Liu, Aijie Chen, Baoxu Li, Shibin Li, Weibin Huang, Qi Xie, Fucheng Tao, Leyao Su, Kairan Zhu, Qi Liu and 1 more

Abstract read
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In one paragraph

Article in Journal of bioenergetics and biomembranes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhongshuang Liu *Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1298 Xueyuan Blvd, Nanshan, Shenzhen, Guangdong, 518055, P.R. China.
Aijie Chen *Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Baoxu LiSchool of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Shibin LiSchool of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Weibin HuangSchool of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Qi XieSchool of Stomatology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, 150000, China.
Fucheng TaoDepartment of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1298 Xueyuan Blvd, Nanshan, Shenzhen, Guangdong, 518055, P.R. China.
Leyao SuSchool of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Kairan ZhuSchool of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China.
Qi LiuInternational Cancer Center, Shenzhen University School of Medicine, Shenzhen University, 1066 Xueyuan Blvd, Nanshan, Shenzhen, Guangdong, 518055, P.R. China. liu_qi@szu.edu.cn.
Lin MaDepartment of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1298 Xueyuan Blvd, Nanshan, Shenzhen, Guangdong, 518055, P.R. China. malin2021@szu.edu.cn.

Funding

National Key Promotion Project for Health Technologies XM202403986National Natural Science Foundation of China 82401178Research Cultivation Program of Stomatological Hospital of Southern Medical University RC202501Shenzhen Science and Technology Program JCYJ20220531103014033Southern Medical University Higher Education Teaching Reform Project ZL2025176
6 · The paper itself

Abstract

Oxidative stress-mediated impairment of osteoblast function is a critical pathological basis for the development and progression of various bone metabolic diseases. BicC family RNA binding protein 1 (BICC1) plays important roles in osteoblast function, however, the underlying mechanism remains unclear. This study aimed to investigate the protective role of BICC1 in oxidative stress-induced osteogenic injury and the underlying mechanism. An oxidative injury model was established in MC3T3-E1 cells using 300 µM hydrogen peroxide (H

Indexed as

Ketone OxidoreductasesOsteoblastsOsteogenesisOxidative StressPyruvate Dehydrogenase Acetyl-Transferring KinaseRNA-Binding Proteins3-Phosphoinositide-Dependent Protein KinasesAnimalsApoptosisCell DifferentiationHydrogen PeroxideMiceProtein Serine-Threonine KinasesSignal Transduction3-Phosphoinositide-Dependent Protein KinasesHydrogen PeroxideKetone OxidoreductasesPdk1 protein, mousePdpk1 protein, mouseProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseRNA-Binding ProteinsBICC1Osteogenic differentiationOsteoporosisOxidative stressPDK1

Identifiers

PMID42709265

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.