Evidence map›Paper›PMID 42709284›Full record

ReviewBiomedical microdevices2026

Nanomedicine beyond carriers - devices, cells & living therapeutics.

Alessandro Grattoni, Marco Maria Paci, Noah Arnold, Santosh Aryal, Natalie Artzi, Gang Bao, Allan John R Barcena, Einav Bentov-Arava, Elvin Blanco, Corrine Ying Xuan Chua and 37 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedical microdevices, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Alessandro Grattoni *Center for BioNanoengineering, Houston Methodist Hospital, Houston, TX, USA. agrattoni@houstonmethodist.org.
Marco Maria Paci *Center for BioNanoengineering, Houston Methodist Hospital, Houston, TX, USA.
Noah ArnoldDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA.
Santosh AryalDepartment of Pharmaceutical Sciences & Health Outcomes, University of Texas at Tyler, Tyler, TX, USA.
Natalie ArtziInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gang BaoDepartment of Bioengineering, Rice University, Houston, TX, USA.
Allan John R BarcenaDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Einav Bentov-AravaSchool of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Elvin BlancoCenter for BioNanoengineering, Houston Methodist Hospital, Houston, TX, USA.
Corrine Ying Xuan ChuaCenter for BioNanoengineering, Houston Methodist Hospital, Houston, TX, USA.
Bruna CorradettiCenter for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
Alexander M CryerInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Paolo DecuzziLaboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology, Genova, Italy.
Marco De GiorgiDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
Cody FellDepartment of Bioengineering, Rice University, Houston, TX, USA.
Weiwei GaoAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, USA.
Balaji GovindaswamyDepartment of Neurology, McGovern Medical School, UTHealth Houston, Houston, TX, USA.
Wen JiangDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Goknur KaraCenter for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA.
Michael R KingDepartment of Bioengineering, Rice University, Houston, TX, USA.
Sunil KrishnanDepartment of Neurosurgery, Vivian L. Smith, UTHealth, Houston, TX, USA.
William R LagorDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
Twan LammersInstitute for Experimental Molecular Imaging and Nanomedicine, RWTH Aachen University Clinic, Aachen, Germany.
Jessica LarsenDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA.
Francesco ManfrediCenter for BioNanoengineering, Houston Methodist Hospital, Houston, TX, USA.
Devika Soundara ManickamDepartment of Neurology, McGovern Medical School, UTHealth Houston, Houston, TX, USA.
Katy MargulisSchool of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Marites Pasuelo MelanconDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Silvie MeeuwissenArdena Oss BV, Nanomedicines, Oss, The Netherlands.
Michael A MillerDepartment of Medicine, Division of Nephrology & Hypertension, Stony Brook University, Stony Brook, NY, USA.
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Samir MitragotriJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, USA.
Anahita MojiriDepartment of Cardiovascular Sciences, DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TX, USA.
John P CookeDepartment of Cardiovascular Sciences, DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TX, USA.
Rohan PalankiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Imonkanta PhukanDepartment of Chemistry, The University of Texas at Austin, Austin, TX, USA.
Xianwei SunDepartment of Radiology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.
Patrick S StaytonDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Eric A TanifumDepartment of Radiology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.
Omid VeisehDepartment of Bioengineering, Rice University, Houston, TX, USA.
Sonia VillapolCenter for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, USA.
Jingyi WangCenter for BioNanoengineering, Houston Methodist Hospital, Houston, TX, USA.
Ryan WilliamsDepartment of Medicine, Division of Nephrology & Hypertension, Stony Brook University, Stony Brook, NY, USA.
Ravit Yakobi ArancibiaSchool of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Liangfang ZhangAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, USA.
Alexander KabanovUNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Biana GodinCenter for BioNanoengineering, Houston Methodist Hospital, Houston, TX, USA. bgodin@houstonmethodist.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomedicine has progressed far beyond its early role as an experimental drug-carrier toolbox and today stands as a clinically validated enabling technology. Liposomal formulations and albumin-bound nanoparticles have transformed cancer therapy, while lipid nanoparticle (LNP) platforms accelerated the rapid development and global deployment of SARS-CoV-2 mRNA vaccines-demonstrating how nanoscale engineering can reshape therapeutic response, manufacturing speed, and public health impact. With these successes as foundation, the field is rapidly expanding into more sophisticated delivery systems including cell-hitchhiking nanoparticles, biomimetic multivalent vaccines, implantable immunotherapy depots, high-loading polymeric micelles, organ-targeted gene and RNA carriers, and bio-hybrid extracellular vesicle and mitochondrial therapies. These platforms aim not only to transport drugs, but to modulate immunity, direct regeneration, and enable precision intervention at the cellular and molecular scale. This perspective summarizes the current landscape of biomedical nanotechnologies and outlines how their continued evolution positions nanomedicine as an enabling science driving the next generation of therapeutics.

Indexed as

NanomedicineAnimalsCOVID-19Drug CarriersDrug Delivery SystemsHumansImmunotherapyNanoparticlesSARS-CoV-2Drug CarriersDrug deliveryExtracellular vesiclesGene and RNA therapeuticsImmunotherapyNanomedicineNanotheranostics

Identifiers

PMID42709284
PMCPMC13553663

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.