Evidence map›Paper›PMID 42709376›Full record

ArticleBiological trace element research2026

Selenium, Selenoprotein P, and Gut Dysbiosis are Associated with Cartilage Damage in Osteoarthritis Patients.

Tatiana V Korobeinikova, Anatoly V Skalny, Ali F Aliyev, Nelli I Remizova, Galina D Morozova, Konstantin S Ternovoy, Alexey A Kovalenko, Michael Aschner, Feng Zhang, Andrey O Plotnikov and 4 more

Abstract read
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Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tatiana V KorobeinikovaCenter of Bioelementology and Human Ecology, Department of Medical Rehabilitation, University Clinical Hospital No 2, Sechenov First Moscow State Medical University, Moscow, 119146, Russia.
Anatoly V SkalnyCenter of Bioelementology and Human Ecology, Department of Medical Rehabilitation, University Clinical Hospital No 2, Sechenov First Moscow State Medical University, Moscow, 119146, Russia.
Ali F AliyevCenter of Bioelementology and Human Ecology, Department of Medical Rehabilitation, University Clinical Hospital No 2, Sechenov First Moscow State Medical University, Moscow, 119146, Russia.
Nelli I RemizovaCenter of Bioelementology and Human Ecology, Department of Medical Rehabilitation, University Clinical Hospital No 2, Sechenov First Moscow State Medical University, Moscow, 119146, Russia.
Galina D MorozovaCenter of Bioelementology and Human Ecology, Department of Medical Rehabilitation, University Clinical Hospital No 2, Sechenov First Moscow State Medical University, Moscow, 119146, Russia.
Konstantin S TernovoyCenter of Bioelementology and Human Ecology, Department of Medical Rehabilitation, University Clinical Hospital No 2, Sechenov First Moscow State Medical University, Moscow, 119146, Russia.
Alexey A KovalenkoCenter of Bioelementology and Human Ecology, Department of Medical Rehabilitation, University Clinical Hospital No 2, Sechenov First Moscow State Medical University, Moscow, 119146, Russia.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Feng ZhangKey Laboratory of Trace Elements and Endemic Diseases, Health Science Center, School of Public Health, National Health and Family Planning Commission, Xi'an Jiaotong University, Xi'an, 710061, China.
Andrey O PlotnikovInstitute of Cellular and Intracellular Symbiosis, Orenburg Federal Research Center, Ural Branch of the Russian Academy of Sciences, Orenburg, 460000, Russia.
Yuriy A KhlopkoInstitute of Cellular and Intracellular Symbiosis, Orenburg Federal Research Center, Ural Branch of the Russian Academy of Sciences, Orenburg, 460000, Russia.
Guo XiongKey Laboratory of Trace Elements and Endemic Diseases, Health Science Center, School of Public Health, National Health and Family Planning Commission, Xi'an Jiaotong University, Xi'an, 710061, China.
Viktor A GritsenkoInstitute of Cellular and Intracellular Symbiosis, Orenburg Federal Research Center, Ural Branch of the Russian Academy of Sciences, Orenburg, 460000, Russia.
Alexey A TinkovCenter of Bioelementology and Human Ecology, Department of Medical Rehabilitation, University Clinical Hospital No 2, Sechenov First Moscow State Medical University, Moscow, 119146, Russia. tinkov.a.a@gmail.com.

Funding

National Natural Science Foundation of China 82361138566Russian Science Foundation 24-45-00073
6 · The paper itself

Abstract

The objective of the present study was to evaluate markers of selenium (Se) metabolism and taxonomic characteristics of gut microbiota, as well as their relationship to markers of inflammation and cartilage damage in patients with osteoarthritis (OA). The study enrolled 50 healthy controls, 45 patients with knee OA (kOA), and 41 patients with knee and one-sided hip OA (khOA). Serum selenoprotein P (SELENOP), cartilage oligomeric matrix protein (COMP), lipopolysaccharide (LPS), C-reactive protein (CRP), as well as C3 and C5a complement components were assessed. Serum, hair, and urinary Se levels were evaluated using inductively coupled plasma-mass spectrometry (ICP-MS). Fecal microbiota taxonomy was evaluated by high-throughput sequencing. Patients with kOA and especially khOA were characterized by higher COMP and CRP levels. LPS concentration also tended to be higher in khOA patients. The lowest serum Se and SELENOP levels were observed in khOA patients. The richness of Bacteroidota phylum, classes Bacteroidia and Negativicutes was increased, whereas the abundance of Coriobacteriia was lower in OA patients compared to controls. The relative abundance of families Actinomycetaceae, Anaerovoracaceae, Clostridiaceae, Eggerthellaceae, Lactobacillaceae, Peptostreptococcaceae, Streptococcaceae, and unclassified_Clostridia UCG-014 was reduced in OA patients, while Oscillospiraceae and Prevotellaceae were enriched. Significant group differences were also observed in the richness of certain bacterial genera. Multiple linear regression analysis revealed inverse association between SELENOP and LPS concentrations, while COMP concentration was associated with C5a and SELENOP levels in a positive and negative manner, respectively. Certain bacterial taxa were also considered significant predictors of SELENOP and COMP levels. Therefore, these novel data establish that gut dysbiosis is associated with both cartilage damage and altered Se metabolism in OA.

Identifiers

PMID42709376

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.