Evidence map›Paper›PMID 42709793›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Mitochondrial depolarization stabilizes the vitamin B

Sneha P Rath, Zhu Li, Arkajit Guha, Fangcong Dong, Ruma Banerjee, Vamsi K Mootha

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mitochondrial depolarization stabilizes the vitamin BProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sneha P Rath *Department of Molecular Biology, Mass General Hospital, Boston, MA 02114.ORCID 0000-0001-8839-1285
Zhu Li *Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109.
Arkajit GuhaDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109.
Fangcong DongDepartment of Molecular Biology, Mass General Hospital, Boston, MA 02114.
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-8332-3275
Vamsi K MoothaDepartment of Molecular Biology, Mass General Hospital, Boston, MA 02114.ORCID 0000-0001-9924-642X

Funding

REACTION MECHANISMS OF MAMMALIAN B12-DEPENDENT ENZYMESR01DK045776 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI RUMA V BANERJEE · 1998 to 2026
$9.7M
Molecular Determinants of Mitochondrial Genome Abundance and IntegrityK00CA212468 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RATH, SNEHA PRAKASH · 2019 to 2022
$385k
A Systems Approach to Discover Sensors and Regulators of the Mitochondrial GenomeK99GM145848 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI RATH, SNEHA PRAKASH · 2023 to 2024
$250k
HHMI (HHMI) Investigator AwardHHS | NIH | National Cancer Institute (NCI) K00CA212468HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK45776HHS | NIH | National Institute of General Medical Sciences (NIGMS) K99GM145848NCI NIH HHS K00 CA212468NIDDK NIH HHS R01 DK045776NIGMS NIH HHS K99 GM145848
6 · The paper itself

Abstract

Of the ~1,100 mitochondrial proteins, only a handful like PINK1 and ATFS-1 are known to stabilize and relocalize upon collapse of the proton motive force (PMF) to execute signaling roles. To systematically identify genes that increase exclusively at the protein level upon PMF collapse, we performed a joint proteomic and RNA-seq screen. The screen revealed 10 candidates (six mitochondrial), including two genes in vitamin B

Indexed as

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseCytosolMitochondriaMolecular ChaperonesVitamin B 12HumansMitochondrial ProteinsProton-Motive Force5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseMitochondrial ProteinsMolecular ChaperonesVitamin B 12methionine synthasemitochondriaMMADHCproton motive forcevitamin B12

Identifiers

PMID42709793
PMCPMC13578772

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.