Evidence map›Paper›PMID 42711072›Full record

ArticleBMJ open2026

Impact of PerioperAtive LidocAine Infusions on Enhanced Recovery After Noncardiac Surgery (IMPALA-ERAS) in an inpatient setting: rationale, design and protocol for a sequential, repeated crossover trial.

Gerald W Rouleau, Aden W Smith, Crystal G Parrish, Leslie J Allen, Jennifer E Jayaram, Sydney R Ruble, Claire M Adkins, Svetlana Eden, Matthew S Shotwell, Edward T Yaghmour and 6 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07224711 (The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07224711 phase4not yet recruitingnot on this map

The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (IMPALA ERAS)

TypeinterventionalSponsorVanderbilt University Medical CenterRan2026 to 2028Enrolled2,290ConditionsPain, Post Operative Analgesia, Opioid Consumption, PostoperativeArmsLidocaine HCl 0.8% in D5W, Sodium Chloride 0.9%
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gerald W RouleauAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Aden W SmithVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Crystal G ParrishAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Leslie J AllenAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jennifer E JayaramAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sydney R RubleAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Claire M AdkinsEnterprise Analytics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Svetlana EdenBiostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Matthew S ShotwellBiostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Edward T YaghmourAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Nicholas J StatzerAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jonathan P WandererAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Christopher Patrick HensonAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID http://orcid.org/0000-0002-1357-026X
Danial ShamsAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Miklos D KertaiAnesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA miklos.kertai@vumc.org.ORCID http://orcid.org/0000-0001-6611-7998
IMPALA Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMultimodal analgesic strategies designed to minimise perioperative opioid exposure are fundamental components of enhanced recovery after surgery (ERAS) pathways. Despite widespread implementation of ERAS protocols, the optimal analgesic regimen remains undefined, as the individual contributions of specific agents to overall analgesic efficacy and opioid-sparing effects are not fully elucidated. Intravenous lidocaine, a widely utilised local anaesthetic, possesses both analgesic and anti-inflammatory properties and has been associated with improved gastrointestinal recovery. This study seeks to pragmatically evaluate the impact of incorporating perioperative intravenous lidocaine infusion into established ERAS pathways on postoperative functional recovery. METHODS AND ANALYSIS: The ETHICS AND DISSEMINATION: This protocol and accompanying statistical analysis plan outline the study design, primary and secondary endpoints and analytic methodology. The IMPALA-ERAS trial has received ethical approval from the Vanderbilt University Institutional Review Board (IRB: 250617). The findings will be disseminated via peer-reviewed publications and presentations at national conferences. Results from this trial are expected to inform evidence-based practices regarding perioperative lidocaine infusion and its potential contributions to enhanced postoperative recovery in surgical patients. TRIAL REGISTRATION NUMBER: NCT07224711.

Indexed as

Anesthetics, LocalEnhanced Recovery After SurgeryLidocainePerioperative CarePostoperative PainAdultCross-Over StudiesDouble-Blind MethodFemaleHumansInfusions, IntravenousLength of StayPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicResearch DesignAnesthetics, LocalLidocaineAdult anaesthesiaAdult surgeryPAIN MANAGEMENT

Identifiers

PMID42711072
PMCPMC13561014

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.