ReviewJournal of menopausal medicine2026
Clinical Significance of Bone Turnover Markers in Osteoporosis: Fracture Risk Assessment and Treatment Monitoring.
Review in Journal of menopausal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a systemic skeletal disorder characterized by compromised bone strength and a higher risk of fractures. Although bone mineral density (BMD) remains the primary diagnostic measure, it has several limitations, including delayed detection of therapeutic response, restricted measurement sites, and limited sensitivity to predict fracture risk accurately. Bone turnover markers (BTMs) are noninvasive indicators of bone remodeling that are increasingly being used as complementary tools in osteoporosis assessment. Among them, serum procollagen type I N-terminal propeptide and C-terminal telopeptide of type I collagen are reference markers of bone formation and resorption. However, BTM levels can be influenced by biological and pathological factors, including circadian rhythms, food intake, and assay variability, thereby limiting their routine use as predictive markers. In individuals at risk of fracture, antiresorptive agents such as bisphosphonates and denosumab cause rapid alterations in BTMs, which correlate with long-term gains in BMD and reduced fracture risk. Monitoring BTMs can help evaluate therapeutic efficacy and adherence and complement BMD measurement in fracture risk prediction. Overall, rather than being used as stand-alone diagnostic markers, BTMs should be used as complementary tools for monitoring therapeutic responses and supporting fracture risk assessment.
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Registered trials
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