ArticleJournal of clinical lipidology2026
Investigating the associations between prepregnancy lipoprotein(a) and birth outcomes: The Hispanic Community Health Study/Study of Latinos.
Article in Journal of clinical lipidology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLipoprotein(a) [Lp(a)] is an atherosclerotic risk factor that may influence adverse pregnancy complications, although mechanisms remain poorly understood. Evidence linking Lp(a) with pregnancy outcomes relies on small cross-sectional studies, nonuniform Lp(a) measurement across pregnancy, and isoform-sensitive assays.
methodsWe identified 508 women with singleton live birth >43 weeks after baseline (2008-2011). Self-reported outcomes at second visit include: gestational diabetes mellitus (GDM, n = 80 [16%]), hypertensive disorders of pregnancy (HDP, n = 55 [11%]), preterm birth (PTB, n = 55 [11%]), small for gestational age (SGA, n = 37 [8%]), and birth weight Z-score (BWZ, n = 483). Adverse pregnancy outcome (APO, n = 179 [37%]) was defined as the presence of GDM, HDP, PTB, or SGA. Confounder-adjusted (age, kidney function, Hispanic/Latino background) logistic regression examined linear, curvilinear, quartile-categorized, and binary risk-threshold (≥75 nmol/L) patterns.
resultsBaseline mean age was 26.4 (SD = 5.8), almost half were of Mexican background, and the Lp(a) median = 16.9 nmol/L (range: 2.8-415.1; IQR: 6.7-52.8 nmol/L; n = 93 [18%] with Lp(a) >75 nmol/L). Lp(a) >75 nmol/L had an odds ratio of 0.77 for HDP (95%CI: 0.31-1.92) and 0.86 for PTB (95%CI: 0.32-2.32), both imprecise and did not reach statistical significance. The curvilinear model, though imprecise, suggested an inverted U-shaped dose-response pattern for odds of GDM and HDP, while PTB and BWZ showed downward and upward trends, respectively, across increasing Lp(a). Other associations showed no clear pattern.
conclusionsPrepregnancy Lp(a) may exhibit a U-shaped dose-response with HDP and GDM, and a downward trend in PTB; however, there were no definite associations. Future work with larger samples is needed to understand the physiological implications of Lp(a) for pregnancy.
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