ArticleCell biochemistry and biophysics2026
Vestitol Ameliorates Ferroptosis-Associated Features and Osteoarthritis Progression Through Modulation of the GSK3B/Nrf2/GPX4 Pathway.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to investigate whether vestitol ameliorates osteoarthritis (OA) and the mechanisms involved. We employed destabilization of the medial meniscus (DMM)-constructed OA mouse model and IL-1β-induced chondrocyte model to evaluate vestitol's effects on OA. In vivo, pathological alterations in cartilage tissues were assessed via safranin O and H&E staining. In vitro, chondrocyte viability and apoptosis were detected utilizing CCK-8 and flow cytometry. Vestitol's mechanisms in OA were explored using network pharmacology analysis. Factors related to extracellular matrix (ECM) degeneration, inflammation, oxidative stress, ferroptosis, and pathway were checked using western blot, RT-qPCR, immunohistochemistry, and corresponding commercial reagent kits. In OA mice model, vestitol decreased cartilage destruction and OARSI score. Vestitol enhanced the levels of COL2A1, Aggrecan, SOD, FTH1, but reduced the levels of MMP-13, ADAMTS5, IL-6, IL-1β, COX-2, TNF-α, MDA, Fe
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