Evidence map›Paper›PMID 42711921›Full record

ArticleChemical biology & drug design2026

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N-Cinnamamide/Benzamide-(4-(Substituted Phenyl)-6-(4-Cyclohexylphenyl)pyrimidin-2-Yl) Derivatives as EGFR Inhibitors Targeting EGFR

Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Manjushree Bv, Anguraj Moulishankar, Viney Chawla, Pooja A Chawla

Erratum issuedAbstract read
In one paragraph

Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rohit PalDepartment of Pharmaceutical Chemistry, Integrated Drug Discovery Centre, Acharya & BM Reddy College of Pharmacy, Bengaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-2763-5757
Gurubasavaraja Swamy Purawarga MatadaDepartment of Pharmaceutical Chemistry, Integrated Drug Discovery Centre, Acharya & BM Reddy College of Pharmacy, Bengaluru, Karnataka, India.ORCID https://orcid.org/0000-0002-1978-6029
Ghanshyam TeliSchool of Pharmacy, Sangam University, Bhilwara, Rajasthan, India.ORCID https://orcid.org/0000-0002-7418-6683
Manjushree BvDepartment of Pharmaceutical Chemistry, Integrated Drug Discovery Centre, Acharya & BM Reddy College of Pharmacy, Bengaluru, Karnataka, India.ORCID https://orcid.org/0009-0000-1709-8989
Anguraj MoulishankarDepartment of Pharmaceutical Chemistry, Integrated Drug Discovery Centre, Acharya & BM Reddy College of Pharmacy, Bengaluru, Karnataka, India.ORCID https://orcid.org/0000-0003-3694-4321
Viney ChawlaUniversity Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot, Punjab, India.ORCID https://orcid.org/0000-0001-8522-7148
Pooja A ChawlaUniversity Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot, Punjab, India.ORCID https://orcid.org/0000-0001-7844-9172

Funding

Indian Council of Medical Research 5/13/12/2020/NCD-IIIIndian Council of Medical Research 5/13/79/2020/NCD-IIIIndian Council of Medical Research IIRPSG-2024-01-01202
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC), driven by mutations in the epidermal growth factor receptor (EGFR), presents significant therapeutic challenges, particularly due to drug resistance. This study describes the design, synthesis, and evaluation of a series of novel N-Cinnamamide/benzamide-(4-(substituted phenyl)-6-(4-cyclohexylphenyl)pyrimidin-2-yl) derivatives (Ri-Rxii) as EGFR inhibitors. Among these, compound Riv exhibited superior antiproliferative activity against wild-type and mutant EGFR-driven NSCLC cell lines, including EGFR

Indexed as

Antineoplastic AgentsBenzamidesCinnamatesDrug DesignProtein Kinase InhibitorsPyrimidinesApoptosisCarcinoma, Non-Small-Cell LungCell Line, TumorCell ProliferationErbB ReceptorsHumansLung NeoplasmsMolecular Docking SimulationMutationTyrosine Kinase InhibitorsAntineoplastic AgentsBenzamidescinnamamideCinnamatesEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsPyrimidinesTyrosine Kinase InhibitorsADMETdockingEGFRlung cancerpyrimidine

Identifiers

PMID42711921
PMCPMC13554467

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.