Evidence map›Paper›PMID 42712094›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Shared genetic architecture between DTI-ALPS traits and neurodegenerative diseases.

Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, Beisha Tang, Xinhua Wei, Lu He and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hong Zhou *Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.ORCID https://orcid.org/0000-0002-6460-3420
Jialin Deng *Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Qian Wu *Department of Radiology, Tianjin Key Lab of Functional Imaging and Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, China.
Yule ZengDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Tianyao WangDepartment of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jiayi WuDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Xiaomei DuanClinical Research Center for Immune-Related Encephalopathy of Hunan Province, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Beisha TangClinical Research Center for Immune-Related Encephalopathy of Hunan Province, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Xinhua WeiDepartment of Radiology, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, China.
Lu HeDepartment of Neurosurgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Feng LiuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, China.

Funding

Clinical Research 4310 Program of the First Affiliated Hospital of the University of South China 20224310NHYCG03Innovation Platform and Talent Program 2023TP1047National Science and Technology Major Project 2024ZD0528203
6 · The paper itself

Abstract

introductionDiffusion tensor image analysis along the perivascular space (DTI-ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear.

methodsBy integrating genome-wide association datasets for three DTI-ALPS traits and seven NDDs, we quantified polygenic overlap using MiXeR, identified shared loci using conditional and conjunctional false discovery rate analyses, and performed gene mapping, enrichment, temporal expression, and transcriptome-wide association analyses.

resultsDTI-ALPS traits showed widespread but heterogeneous polygenic overlap with NDDs. We identified 22 shared loci, including novel associations implicating GAK and SIAH3, with the strongest convergence at 17q21.31. Shared loci mapped to 183 protein-coding genes enriched in the endolysosomal system and microtubule cytoskeleton. These genes showed similar temporal expression patterns, and 45 were associated with both DTI-ALPS traits and NDDs. DISCUSSION: These findings reveal a shared genetic architecture between DTI-ALPS traits and NDDs, highlighting mechanisms that may contribute to their overlap.

Indexed as

Diffusion Tensor ImagingNeurodegenerative DiseasesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMultifactorial Inheritancecross‐trait genetic analysisdiffusion tensor image analysis along the perivascular spaceglymphatic systemneurodegenerative diseasespolygenic architecture

Identifiers

PMID42712094
PMCPMC13554997

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.