Evidence map›Paper›PMID 42712112›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Age-friendly environments and incident motoric cognitive risk syndrome in older adults: A prospective cohort study.

Hui Zhang, Zixin Hu, Chongyu Ding, Yaqian Xu, Shuai Jiang, Yi Li, Jiucun Wang, Xiaofeng Wang, Meng Hao, Xiangwei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui Zhang *School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zixin Hu *Artificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, China.
Chongyu DingSchool of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yaqian XuSchool of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuai JiangDepartment of Vascular Surgery, Shanghai Key Laboratory of Vascular Lesion Regulation and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Yi LiState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.
Jiucun WangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.
Xiaofeng WangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.
Meng HaoHuadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Xiangwei LiSchool of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

Shanghai Jiao Tong University KJ2-0112-23-0002the National Natural Science Foundation of China 82301768the National Natural Science Foundation of China 82574160the Startup Fund for Young Faculty at SJTU KJ3-0214-24-0037
6 · The paper itself

Abstract

introductionMotoric cognitive risk syndrome (MCR) is a predementia condition that predicts multiple adverse health outcomes. Age-friendly environments (AFE) represent a key strategy for promoting healthy aging and may reduce MCR risk. However, little is known about the association between AFE status and MCR risk.

methodsThis prospective cohort study used data from the National Health and Aging Trends Study. AFE status was assessed across eight domains based on the World Health Organization (WHO) framework. MCR was evaluated annually from 2011 to 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs); restricted cubic spline regressions were used to examine dose-response relationships.

resultsA total of 7,608 older adults (mean age: 76.81 ± 7.53 years; 57.32% female) without baseline MCR were included. Over a median follow‑up of 4 years, 801 incident MCR cases occurred. Compared with participants in the lowest quartile (Q1) of AFE scores, those in Q3 (HR 0.75, 95% CI: 0.61-0.91) and Q4 (HR 0.62, 95% CI: 0.50-0.78) had significantly lower MCR risks. Additionally, a dose-response association was observed between higher AFE scores and lower risk of incident MCR (HR 0.96, 95% CI: 0.94-0.98). DISCUSSION: AFE was associated with a decreased risk of incident MCR among older adults. These findings suggest that creating AFE may be a feasible population‑based strategy to delay pre‑dementia syndromes, thereby contributing to dementia prevention.

Indexed as

AgingCognitive DysfunctionEnvironmentAgedAged, 80 and overFemaleHumansIncidenceMaleProportional Hazards ModelsProspective StudiesRisk Factorsage‐friendly environmentscohortmotoric cognitive risk syndrome

Identifiers

PMID42712112
PMCPMC13555024

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.