ArticleFrontiers in immunology2026
IL-1β as an important mediator of macrophage-chondrocyte crosstalk in pararamosis (rainforest arthritis).
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pararamosis, or pararama-associated phalangeal periarthritis, is a neglected tropical disease affecting rubber tappers in the Amazon, caused by contact with the urticating bristles of the Methods: We investigated the inflammatory mechanisms of pararamosis by examining macrophage polarization and the subsequent crosstalk with chondrocytes. THP-1-derived macrophages were treated with Results: PsE stimulation induced a robust M1 macrophage phenotype, evidenced by the upregulation of CD80, CD86, and TLR2, alongside increased expression of inflammasome components ( Conclusion: Our findings demonstrate that PsE promotes a sustained pro-inflammatory macrophage response and establishes a pathogenic crosstalk between macrophages and chondrocytes that amplifies inflammatory and catabolic signaling. The data identify IL-1β as a major regulator of this interaction and support the involvement of inflammasome-related pathways in the response to PsE. These results advance our understanding of the mechanisms underlying pararamosis and reveal biological features shared with osteoarthritis, providing a foundation for future studies aimed at validating the role of IL-1β and other inflammatory mediators
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