ArticleFrontiers in psychiatry2026
Association between psychological resilience and global health status/quality of life in patients with brain metastases after resection of primary non-small cell lung cancer.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Brain metastases after resection of primary non-small cell lung cancer (NSCLC) impose substantial burdens. We examined the concurrent association between psychological resilience and global health status/quality of life (GHS/QoL). Methods: This single-center retrospective study included 207 adults who first developed brain metastases after primary NSCLC resection. Records from the 25-item Connor-Davidson Resilience Scale (CD-RISC), European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Brain Neoplasm Module 20 (EORTC QLQ-BN20), collected at the same clinically stable outpatient assessment 4-12 weeks after brain-metastasis diagnosis, were linked to retrospectively extracted clinical data. Pearson correlations and a prespecified full-covariate multivariable linear regression model were used. Results: CD-RISC scores correlated positively with all QLQ-C30 functioning scales and GHS/QoL and negatively with the three QLQ-C30 symptom scales and four QLQ-BN20 multi-item symptom scales (all Benjamini-Hochberg-adjusted Conclusions: Greater psychological resilience was concurrently associated with better GHS/QoL and lower QLQ-BN20 multi-item symptom scores. These findings support integrated assessment of resilience, function, and symptoms; temporal direction requires longitudinal confirmation, and intervention effects require prospective trials.
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