ED95 determination of continuous norepinephrine infusion for preventing spinal anesthesia-induced hypotension in obese parturients during cesarean delivery.

Rui Ran, Limeng Liu, Wenqian Li, Jing Li, Xiaofeng Lei, Jin Yu

Abstract readClinical Trial

In one paragraph

Trial report in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rui RanDepartment of Anesthesiology, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.

Limeng LiuDepartment of Anesthesiology, First Clinical College, Chongqing Medical University, Chongqing, China.

Wenqian LiDepartment of Anesthesiology, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.

Jing LiDepartment of Anesthesiology, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.

Xiaofeng LeiDepartment of Anesthesiology, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.

Jin YuDepartment of Anesthesiology, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Norepinephrine is an effective vasopressor for preventing and managing spinal anesthesia-induced hypotension during cesarean delivery. Nevertheless, data regarding the 95% effective dose (ED Methods: This prospective dose-finding study enrolled parturients scheduled for elective cesarean delivery under spinal anesthesia. Participants were stratified into two groups based on body mass index (BMI): non-obese group (BMI <30 kg/m Results: Eighty parturients were included in the analysis. The ED Conclusion: The findings indicate that obese parturients require a significantly higher prophylactic dose of norepinephrine infusion to prevent spinal anesthesia-induced hypotension compared to the non-obese counterparts. These results underscore the importance of individualized dosing strategies based on BMI to optimize hemodynamic management in obese parturients undergoing cesarean delivery.

Indexed as

cesarean deliverydose-findingnorepinephrineobesityspinal hypotension

Identifiers

PMID42712682

DOI10.3389/fphar.2026.1905008

PMCPMC13550186

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.