In one paragraphArticle in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Maxime C M van den OetelaarLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0002-1224-4171 Leandre RavattGerman Center for Neurodegenerative Diseases (DZNE) Department Charité University Medicine, Charitéplatz 1 10117 Berlin Germany susanne.wegmann@dzne.de.
Francisco Maqueda ZelayaLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0002-9962-159X Ansgar OberheideLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0003-3664-5428 Tom R van de WijngaartLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0009-0008-8968-909X Floor M A van BoxtelLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0009-0005-2519-1960 Marloes A M PenningsLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0002-3366-0238 Carlo J A VerhoefLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0001-5720-1602 Thijs W van VeldhuisenLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0003-2304-0294 Peter J CossarLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0002-8260-5710 Christian OttmannLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0001-7315-0315 Luc BrunsveldLaboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands c.ottmann@tue.nl l.brunsveld@tue.nl.ORCID https://orcid.org/0000-0001-5675-511X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The intrinsically disordered protein Tau is highly phosphorylated under pathological conditions, which, among others, results in Tau liquid-liquid phase separation (LLPS), followed by aggregation. The hub protein 14-3-3 regulates Tau protein solubility and prevents LLPS by binding with phosphorylated Tau residues pS214 and pS324. Here, we report the stabilization of this Tau/14-3-3 protein-protein interaction (PPI) using reversible-covalent small-molecule molecular glues. By strengthening the 14-3-3/Tau interaction the molecular glues enhance the effect of 14-3-3 on Tau solubility in LLPS. This demonstrates the potential of modulating the 14-3-3/Tau PPI for novel drug discovery efforts in neurodegenerative diseases.
Identifiers
PMID42712752
PMCPMC13551062
What Socratic holds
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