ReviewInternational journal of nanomedicine2026
Sulfated Polysaccharides in Wound Healing: From Bioactive Materials Design to Regenerative Therapeutics.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sulfated polysaccharides (SPs) are emerging as a versatile class of bioactive macromolecules for wound healing, owing to their intrinsic roles in cell signaling, immunomodulation, tissue repair, and host defense. As wound healing is a dynamic and tightly coordinated process, particularly in chronic and refractory wounds, a central question is how SP-based biomaterials can be engineered to modulate the wound microenvironment with spatiotemporal precision. Natural and engineered SPs offer distinct advantages, including structural diversity, inherent bioactivity, and tunable physicochemical properties. Mechanistically, SPs regulate key aspects of repair through macrophage polarization, sequestration and presentation of heparin-binding proteins and growth factors, antimicrobial activity, and extracellular matrix (ECM) remodeling. Recent advances have enabled SP-based platforms in the form of hydrogels, microneedles, microspheres, and nanofibrous scaffolds, which provide biochemical and mechanical cues to orchestrate inflammation resolution, angiogenesis, infection control, and tissue regeneration. This Review outlines the sources, structural features, and engineering strategies of SPs, highlights the transition from natural to engineered systems, and discusses recent progress and translational challenges in SP-based wound therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.