ArticleQatar medical journal2026
Effect of nebivolol on nitric oxide availability and ADMA concentration in CAD patients after PCI: Prospective randomized double-blind study.
Article in Qatar medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endothelial dysfunction, defined by decreased bioavailability of nitric oxide (NO) and increased levels of asymmetric dimethylarginine (ADMA), has been proposed to play a central role in Coronary Artery Disease (CAD) pathophysiology. A selective β-blocker, nebivolol, could offer benefits in affecting this pathway after revascularization. Objective: The objective of this study is to determine the influence of nebivolol on serum NO levels and ADMA in patients with CAD who underwent successful elective percutaneous coronary intervention (PCI). Methods: In this prospective randomized double-blind placebo-controlled clinical study, 172 subjects with confirmed obstructive CAD and scheduled for PCI were recruited. After successful revascularization, patients were randomized to receive nebivolol 5 mg once daily ( Results: The baseline clinical parameters and biomarker values were found to be equivalent between groups. After 42 days of therapy, there was a marked increase in serum NO levels among the nebivolol group (from 85.25 ± 9.8 to 128.47 ± 6.2; Conclusion: In patients after PCI, treatment for 42 days was found to significantly enhance NO availability and decrease systemic ADMA concentration by nebivolol. These results clearly establish that nebivolol has the potential to restore vascular homeostasis in the high-risk vascular window, hence making it an ideal supplementary treatment for patients having atherosclerotic diseases.
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