ArticlePolish journal of radiology2026
Exploratory quantitative magnetic resonance imaging characterization of histopathologic subtype heterogeneity in osteosarcoma.
Article in Polish journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Purpose: Osteosarcoma is the most common primary malignant bone tumor in children and young adults and demonstrates substantial histopathologic heterogeneity that complicates diagnosis and treatment monitoring. Conventional imaging and biopsy may not adequately reflect whole-tumor biology because of spatial sampling limitations. Multiparametric magnetic resonance imaging (MRI), including dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI), provides quantitative biomarkers related to tumor vascularity and cellularity. The aim of this study was to evaluate the association between quantitative DCE-MRI parameters and apparent diffusion coefficient (ADC) values across osteosarcoma subtypes and to explore their role in reflecting histopathologic heterogeneity. Material and methods: This retrospective exploratory study included 43 patients with histopathologically confirmed osteosarcoma who underwent pre-treatment 3.0-T MRI, including DCE-MRI and DWI, between January 2023 and February 2025. The cohort consisted of 17 osteoblastic, 9 fibroblastic, 6 chondroblastic, 5 giant cell-rich, 5 telangiectatic, and 1 extraskeletal osteosarcoma cases. Quantitative pharmacokinetic parameters (K Results: K Conclusions: Quantitative DCE-MRI parameters, particularly K
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