ArticleJournal of oral microbiology2026
Integrative meta-analysis of the OSCC microbiome: from niche-specific heterogeneity to universal network and functional signatures.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: While the association between oral squamous cell carcinoma (OSCC) and microbial dysbiosis is well-established, high inter-study heterogeneity has historically hindered the identification of universal biomarkers. Objective: To explore the profound influence of anatomical ecological niches on microbial profiles while identifying shared oncogenic signatures across diverse populations. Design: An integrative meta-analysis of independent OSCC microbiome cohorts was conducted. Results: Our results demonstrate that microbial community composition is predominantly driven by the sampling site rather than the disease state alone, with tissue-derived samples forming a distinct ecological cluster. Despite this site-specific dominance, a consistent core of anaerobic pathogens-including Conclusions: These findings emphasize the necessity of standardizing sampling protocols and provide a robust scientific basis for non-invasive, saliva-based precision diagnostic strategies for OSCC.
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Registered trials
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