Evidence map›Paper›PMID 42713112›Full record

ArticleFuture virology2026

When defense backfires: inflammatory determinants of RSV-induced disease severity.

Alexandra Y Chasse, Ann M Miller, Steven M Varga

Abstract read
In one paragraph

Article in Future virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexandra Y ChasseDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7970-2053
Ann M MillerDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-5484-188X
Steven M VargaDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7332-4290

Funding

Deciphering the complexities of inflammasome activation following RSV infectionR01AI167249 · NIAID · UNIVERSITY OF IOWA · PI Steven M Varga · 2022 to 2026
$3.3M
NIAID NIH HHS R01 AI167249
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) poses a widespread global burden that typically causes mild, cold-like symptoms in infected healthy adults. However, in vulnerable populations, such as the very young or older adults, RSV infection can lead to severe and potentially fatal disease. Both viral and host factors play a dynamic role in determining disease severity. In the host, dysregulation of both the innate and adaptive immune responses can result in unrestrained viral replication and excessive inflammation. Insight has been gained into the host factors that drive more severe disease following RSV infection using animal models and clinical studies. In this review, we discuss both clinical and

Indexed as

CD4 T cellCD8 T cellinfectioninflammationinnate immunitylungRSV

Identifiers

PMID42713112
PMCPMC13552134

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.