Coordinated Hippo, IFN and NF-κB pathway activation in kidney rejection.

Eda Balkan, Murat Kızılkaya, Mahmut Aktürk, Elif Demirci, Necip Altundaş

Abstract read

In one paragraph

Article in Open medicine (Warsaw, Poland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eda BalkanDepartment of Medical Biology, Tissue Typing and Transplant Immunology Laboratory, Faculty of Medicine, Atatürk University, Erzurum, Türkiye.ORCID https://orcid.org/0000-0002-7065-8161

Murat KızılkayaDepartment of Medical Biology, Faculty of Medicine, Ağrı İbrahim Çeçen University, Ağrı, Türkiye.ORCID https://orcid.org/0000-0001-7674-4223

Mahmut AktürkDepartment of Medical Biology, Tissue Typing and Transplant Immunology Laboratory, Faculty of Medicine, Atatürk University, Erzurum, Türkiye.ORCID https://orcid.org/0000-0003-0200-4577

Elif DemirciDepartment of Pathology, Faculty of Medicine, Atatürk University, Erzurum, Türkiye.ORCID https://orcid.org/0000-0002-6660-3870

Necip AltundaşDepartment of General Surgery, Faculty of Medicine, Atatürk University, Erzurum, Türkiye.ORCID https://orcid.org/0000-0002-5165-638X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Renal allograft rejection diagnosis requires invasive biopsy. We assessed whether peripheral blood mRNA of 14 Hippo, interferon (IFN) and NF-κB pathway genes and 11 serum biomarkers could distinguish acute rejection from stable graft function. Methods: Three groups: biopsy-confirmed acute rejection (n=20), stable graft (n=25), healthy controls (n=30). PBMC mRNA was quantified by qRT-PCR; serum biomarkers by ELISA and spectrophotometry. Statistical analyses used Mann-Whitney Results: Thirteen of 14 genes were upregulated in rejection vs. controls (pFDR<0.01); Conclusions: PBMC

Indexed as

calcineurin inhibitorISG15non-invasive biomarkerrenal transplant rejectionYAP1/TEAD1

Identifiers

PMID42713552

DOI10.1515/med-2026-1516

PMCPMC13552812

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.