ArticleOpen life sciences2026
Immune regulatory networks and gut microbiota-associated targets in endometriosis: an integrative multi-omics and network analysis.
Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Endometriosis is an estrogen-dependent disorder characterized by chronic inflammation, immune dysregulation, and altered hormone metabolism. Although gut microbiota-derived metabolites have been implicated in shaping immune microenvironments and lesion development, the underlying regulatory mechanisms remain incompletely understood. Here, we integrated multi-omics, protein-protein interaction (PPI), SHapley Additive exPlanations (SHAP), and single-cell transcriptomics to identify core targets and delineate their interactions with microbiota-derived metabolites, followed by molecular simulations to evaluate metabolite-target binding stability. In this study, we identified 61 differentially expressed genes (DEGs) associated with microbial metabolites. Among these, MET and SELL emerged as key hub genes, with MET showing a potentially protective association and SELL exhibiting a modest positive association with endometriosis risk. Specific gut microbes, including
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