ArticlePediatric nephrology (Berlin, Germany)2026
The relationship between plasminogen activator inhibitor-1 levels and blood pressure in adolescents with a history of prematurity and/or low birth weight.
Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPrematurity and low birth weight (LBW) are important early-life risk factors that contribute to an increased risk of cardiovascular diseases. Plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the antifibrinolytic system and plays a critical role in vascular remodeling and arterial elasticity. The purpose of this study is to examine the relationship between PAI-1 levels and blood pressure in adolescents with a history of prematurity and/or LBW.
methodsThis observational analytical study was conducted at schools near the Prof. Dr. R.D. Kandou General Hospital, Manado, from July to December 2024, using a cross-sectional study design. The subjects were adolescents aged 13-18 years with a history of prematurity and/or LBW who met the inclusion criteria. Blood pressure was measured using a standardized sphygmomanometer, and PAI-1 levels were assessed through serum blood analysis.
resultsFifty-two adolescents were included, with a median age of 174 months (IQR 156-215). PAI-1 levels were significantly higher in the group with abnormal blood pressure compared to the normal group (15.2 ± 3.3 vs. 7.2 ± 4.3 ng/mL; p < 0.001). In the hypertensive category, the mean PAI-1 was also higher compared to the normal or pre-hypertension group (p < 0.001). There was a moderate positive correlation between PAI-1 levels and systolic blood pressure (r = 0.503; p < 0.001) and diastolic blood pressure (r = 0.443; p = 0.001).
conclusionPAI-1 levels are significantly associated with blood pressure in adolescents with a history of prematurity and/or LBW, supporting its role as a biomarker related to hemodynamic changes and as a screening tool for early vascular dysfunction in high-risk populations.
Indexed as
Identifiers
42714585What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.