Evidence map›Paper›PMID 42714729›Full record

ArticleJournal of behavioral medicine2026

Dimensions of early life adversity and accelerated biological aging in adolescents: an examination of fear-related mechanisms.

Leah Cha, Craig K Enders, Shiloh Cleveland, Katie A McLaughlin, Jennifer A Sumner

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of behavioral medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leah ChaDepartment of Psychology, University of California, Los Angeles, 1285 Psychology Building, Box 951563, Los Angeles, CA, 90095-1563, USA. leah.cha@ucla.edu.ORCID http://orcid.org/0000-0003-1806-8962
Craig K EndersDepartment of Psychology, University of California, Los Angeles, 1285 Psychology Building, Box 951563, Los Angeles, CA, 90095-1563, USA.ORCID http://orcid.org/0000-0002-7048-8369
Shiloh ClevelandDepartment of Psychology, University of California, Los Angeles, 1285 Psychology Building, Box 951563, Los Angeles, CA, 90095-1563, USA.ORCID http://orcid.org/0000-0002-2573-1737
Katie A McLaughlinBallmer Institute, University of Oregon, Eugene, USA.ORCID http://orcid.org/0000-0002-1362-2410
Jennifer A SumnerDepartment of Psychology, University of California, Los Angeles, 1285 Psychology Building, Box 951563, Los Angeles, CA, 90095-1563, USA.ORCID http://orcid.org/0000-0002-0217-7171

Funding

Identifying Early Intervention Targets for Reducing Cardiovascular Risk in Posttraumatic StressR01HL139614 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMNER, JENNIFER A · 2018 to 2022
$3.9M
Child Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8M
Identifying Cardiotoxic Manifestations of Posttraumatic Psychopathology: A Population-based Longitudinal InvestigationR01HL160850 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRADUS, JAIMIE L., SUMNER, JENNIFER A · 2022 to 2025
$2.6M
Evidence-based Treatment for PTSD and Cardiovascular Disease RiskR01HL176899 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jaimie L. Gradus, Brian Shiner · 2025 to 2026
$1.4M
NHLBI NIH HHS R01HL139614NHLBI NIH HHS R01HL160850NHLBI NIH HHS R01HL176899NIH HHS R01MH103291NIH HHS R01MH103291-S2NIMH NIH HHS NIMH T32MH015750
6 · The paper itself

Abstract

Early life adversity (ELA), characterized by threat (experiences involving threat of harm), and not deprivation (absence of expected environmental inputs), has been associated with accelerated biological aging in youth. Although understanding of underlying processes is limited, heightened fear responding is a candidate. In 168 youth, we tested whether threat- and deprivation-related ELA were associated with fear responses across multiple levels of analysis and whether fear responses explained links of threat with accelerated biological aging (advanced pubertal stage and epigenetic age). Youth and caregivers reported on youths' lifetime ELA experiences to compute threat and deprivation composites. Youth reported their pubertal maturation and provided saliva samples for epigenetic age estimation. Fear responses (indexed by skin conductance response [SCR], self-reported fear, and amygdala activation) were collected during a fear conditioning and extinction task (SCR, self-reported fear) and emotional stimulus viewing task (amygdala activation). Multilevel models revealed that greater threat was associated with impaired discrimination between danger and safety cues during conditioning based on self-report and during early extinction based on SCR. Greater deprivation related to enhanced danger-safety discrimination during late conditioning based on SCR. Additionally, only threat was associated with greater left amygdala activation to negative (vs. neutral) stimuli. No evidence of indirect effects was found linking threat with accelerated biological aging. Results suggest that threat-related ELA may correspond to heightened neural sensitivity to danger and reduced danger-safety discrimination, whereas deprivation-related ELA may enhance learning of danger vs. safety cues. Findings indicate potential differential associations between threat- and deprivation-related ELA and fear-related processes.

Indexed as

DeprivationDNA methylation ageEarly life adversityFearPubertal stageThreat

Identifiers

PMID42714729

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.