Evidence map›Paper›PMID 42714769›Full record

ArticleEuropean radiology experimental2026

Imaging tumor microenvironment heterogeneity in oral squamous cell carcinoma using IVIM DWI habitat analysis.

Siyu Li, Xiaofeng Zheng, Yifeng Huang, Jiliang Ren, Yingwei Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siyu LiDepartment of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaofeng ZhengDepartment of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yifeng HuangDepartment of First Dental Clinic, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Research, Institute of Stomatology, Shanghai, China.
Jiliang RenDepartment of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. renjiliang2016@163.com.
Yingwei WuDepartment of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wuyw0103@hotmail.com.ORCID http://orcid.org/0000-0002-6196-6445

Funding

Cross Disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine No. JYJC202107National Natural Science Foundation of China No. 82373114Shanghai Ninth People's Hospital No. 2022hbyjxys-rjl
6 · The paper itself

Abstract

objectiveThe tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC) is spatially heterogeneous and critically influences prognosis. Conventional magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI) metrics average heterogeneity and obscure relevant biological intratumoral patterns. Habitat imaging enables voxel-wise characterization of diffusion-perfusion heterogeneity. MATERIALS AND

methodsEighty-four patients with pathologically confirmed OSCC were prospectively enrolled and underwent preoperative multi-b-value intravoxel incoherent motion (IVIM)-DWI. A voxel-wise habitat imaging framework was applied based on diffusion-related (D

resultsHigh-TSR tumors exhibited higher D

conclusionIVIM-DWI-based habitat imaging provides a noninvasive approach for characterizing diffusion-perfusion heterogeneity in OSCC and may complement histopathological assessment for preoperative risk stratification. KEY POINTS: Question: Can IVIM-DWI-based habitat imaging noninvasively characterize tumor microenvironment heterogeneity and identify imaging features associated with stromal composition, immune infiltration, and nodal metastasis in OSCC?

findingsIVIM-DWI-based habitat imaging identified spatially distinct diffusion-perfusion habitats associated with TSR, TILs, and CLNM, with improved discrimination over conventional whole-tumor diffusion metrics. RELEVANCE STATEMENT: IVIM-DWI-based habitat imaging provides clinically relevant, noninvasive biomarkers of TME features, improving preoperative risk stratification and supporting more precise, individualized therapeutic decisionmaking in OSCC.

Indexed as

Carcinoma, Squamous CellDiffusion Magnetic Resonance ImagingMouth NeoplasmsTumor MicroenvironmentAdultAgedFemaleHumansLymphatic MetastasisMaleMiddle AgedProspective StudiesDiffusion magnetic resonance imagingHead and neck neoplasmsLymphocytes (tumor-infiltrating)Squamous cell carcinoma of head and neckTumor microenvironment

Identifiers

PMID42714769
PMCPMC13558524

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.