Evidence map›Paper›PMID 42714849›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.

Jiabin Duan, Jiaqi Liu, Qingsheng Meng, Jiahao Liu, Sitian Yang, Fang Zhou, Jing Cao

Abstract readReview
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiabin DuanDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Jiaqi LiuThe First Clinical Medical College of, Zhengzhou University, Zhengzhou, Henan, China.
Qingsheng MengDepartment of Anesthesiology and Perioperative Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Jiahao LiuDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Sitian YangThe Second Clinical Medical College of, Zhengzhou University, Zhengzhou, Henan, China.
Fang ZhouDepartment of Occupational and Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Jing CaoDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0000-0003-3124-4780

Funding

| National Natural Science Foundation of China-Henan Joint Fund (-) 82371237Program for Innovative Research Team in Universities of Henan Province 22IRTSTHN028
6 · The paper itself

Abstract

Neurodegenerative diseases are characterized by progressive protein aggregation, mitochondrial dysfunction, neuroinflammation, and cognitive decline, yet effective mechanism-based interventions remain limited. Sirtuin 1 (SIRT1), an NAD

Indexed as

Neurodegenerative DiseasesSirtuin 1AnimalsHumansMitochondriaSIRT1 protein, humanSirtuin 1mitochondrial dysfunctionneurodegenerative diseasesneuroinflammationproteostasisSIRT1therapeutics

Identifiers

PMID42714849
PMCPMC13557145

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.