Evidence map›Paper›PMID 42715302›Full record

ArticleScience advances2026

BCL11B predetermines a persister state in breast cancer that is reversed by TNFα.

Zhen Qi, Gunsagar S Gulati, Rachel Gleyzer, Angera H Kuo, Shaheen S Sikandar, Huiru Bai, William Hai Dang Ho, Dalong Qian, Frederick M Dirbas, Aaron M Newman and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhen QiInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0008-8793-9884
Gunsagar S GulatiInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-2798-6220
Rachel GleyzerInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3437-6271
Angera H KuoInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-6955-9951
Shaheen S SikandarInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-1867-6378
Huiru BaiDepartment of Biology, University of Rochester, Rochester, NY 14620, USA.ORCID 0000-0002-2626-1861
William Hai Dang HoInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-1365-9624
Dalong QianInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Frederick M DirbasDepartment of Surgery, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-3576-6404
Aaron M NewmanInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-1857-8172
Shang CaiInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-0630-7719
Michael F ClarkeInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-6889-4926

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The frequent development of chemoresistance in cancer presents a major clinical challenge, yet the underlying causes of heterogeneous drug responses remain largely elusive. Here, we systematically assessed the cellular differentiation status of human breast cancer cells using single-cell atlases and identified a distinct population of immature basal-like cancer cells marked by

Indexed as

Breast NeoplasmsDrug Resistance, NeoplasmRepressor ProteinsTumor Necrosis Factor-alphaTumor Suppressor ProteinsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansBCL11B protein, humanRepressor ProteinsTumor Necrosis Factor-alphaTumor Suppressor Proteins

Identifiers

PMID42715302
PMCPMC13557094

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.