Evidence map›Paper›PMID 42715328›Full record

ArticleScience advances2026

GSK3β and Plk1 sequentially phosphorylate ATP-citrate lyase to promote homologous recombination.

Shinan Zhou, Xinyu Zhou, Qinfu Chen, Xueying Yuan, Shukai Zhu, Jun Huang, Fangwei Wang, Haiyan Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shinan ZhouDepartment of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0009-0007-1238-0441
Xinyu ZhouMOE Laboratory of Biosystems Homeostasis and Protection, Life Sciences Institute, Zhejiang University, Hangzhou, China.ORCID 0000-0003-2620-7360
Qinfu ChenDepartment of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0003-4581-5329
Xueying YuanMOE Laboratory of Biosystems Homeostasis and Protection, Life Sciences Institute, Zhejiang University, Hangzhou, China.ORCID 0009-0003-7455-3265
Shukai ZhuMOE Laboratory of Biosystems Homeostasis and Protection, Life Sciences Institute, Zhejiang University, Hangzhou, China.ORCID 0009-0005-8248-3521
Jun HuangZhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0002-7837-653X
Fangwei WangDepartment of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0001-5617-282X
Haiyan YanSchool of Medicine, Hangzhou City University, Hangzhou, China.ORCID 0009-0000-4778-7902

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is essential for genome stability. Nuclear production of acetyl-coenzyme A (acetyl-CoA) by ATP-citrate lyase (ACLY) promotes HR, yet how ACLY is regulated during the DNA damage response (DDR) remains unclear. Here, we identify a phosphorylation-dependent signaling axis in which glycogen synthase kinase 3β (GSK3β) and Polo-like kinase 1 (Plk1) act sequentially on ACLY to facilitate HR-mediated repair of DSBs induced by ionizing radiation. Following AKT-dependent phosphorylation of ACLY at Ser

Indexed as

ATP Citrate (pro-S)-LyaseCell Cycle ProteinsGlycogen Synthase Kinase 3 betaHomologous RecombinationProtein Serine-Threonine KinasesProto-Oncogene ProteinsAcetylationBRCA1 ProteinDNA Breaks, Double-StrandedHistonesHumansPhosphorylationPolo-Like Kinase 1Proto-Oncogene Proteins c-aktSignal TransductionATP Citrate (pro-S)-LyaseBRCA1 ProteinCell Cycle ProteinsGlycogen Synthase Kinase 3 betaHistonesPolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-akt

Identifiers

PMID42715328
PMCPMC13557067

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.