Evidence map›Paper›PMID 42715331›Full record

ArticleScience advances2026

Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent.

Dongjun Li, Oluwabukola Bamishaye, Sandi Li, Jingjuan Qiao, Francis Akinlotan, Farzaneh Dorabadizare, Xuxin Chen, Yijan Fan, Yi Yuan, Zongxiang Gui and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Dongjun LiCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0003-0085-1975
Oluwabukola BamishayeCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.ORCID 0009-0002-0569-8500
Sandi LiThe Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0001-8993-6056
Jingjuan QiaoCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-4277-6531
Francis AkinlotanCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Farzaneh DorabadizareCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Xuxin ChenDepartment of Radiation and Cellular Oncology and University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0001-8872-8992
Yijan FanThe Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Yi YuanCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Zongxiang GuiCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Khan HekmatyarCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Éva TóthCentre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans rue Charles Sadron; 45071 Orléans, France.ORCID 0000-0002-3200-6752
Agnès PallierCentre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans rue Charles Sadron; 45071 Orléans, France.
Yiting XuInLighta BioSciences LLC, 5075 Lake Fjord Pass, Marietta, GA 30068, USA.
Yusheng ZhangCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.ORCID 0009-0008-3351-1874
Xiaofeng KeCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.ORCID 0009-0002-5596-7991
Alton B FarrisPathology Department, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0001-5534-7763
Hua YangEye Center, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-4313-6042
Jian-Xiong WangDepartment of Radiology, University of Alabama Birmingham, Birmingham, AL 30322, USA.ORCID 0000-0002-4043-8408
Jennifer CarlisleThe Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Suresh S RamalingamThe Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-0757-3106
Michael KirbergerInLighta BioSciences LLC, 5075 Lake Fjord Pass, Marietta, GA 30068, USA.ORCID 0000-0003-2801-5194
Hans GrossniklausEye Center, Emory University School of Medicine, Atlanta, GA 30322, USA.
Xiaofeng YangDepartment of Radiation and Cellular Oncology and University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0001-9023-5855
Zhiren LiuCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Wei ZhouThe Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-6783-9957
Jenny J YangCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-2310-7658

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Ragini Reiney Kudchadkar · 2009 to 2026
$47.5M
Project 3: Inhibiting FAK to enhance immune checkpoint inhibitor therapy in LKB1-mutant lung adenocarcinomaP01CA257906 · NCI · EMORY UNIVERSITY · PI Yuan Liu · 2022 to 2026
$10.7M
Designing Magnetic Resonance Protein-based Contrast Agents with High RelaxivityR01EB007268 · NIBIB · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2007 to 2015
$3.1M
Developing a pharmacologic approach to treat LKB1 mutant NSCLC patientsR01CA194027 · NCI · EMORY UNIVERSITY · PI GILBERT-ROSS, MELISSA, MARCUS, ADAM I. · 2016 to 2020
$2.5M
Noninvasive Contrast Enhanced Early Detection of Melanoma Liver MetastasisR42CA183376 · NCI · INLIGHTA BIOSCIENCES, LLC · PI YANG, JENNY J. · 2017 to 2019
$2.0M
Detection and Staging of Liver Fibrosis by Precise MRI (pMRI)R42AA025863 · NIAAA · INLIGHTA BIOSCIENCES, LLC · PI YANG, JENNY J. · 2018 to 2020
$2.0M
Development of a Novel MRI Contrast Agent for Early Detection of Alcoholic SteatohepatitisUT2AA028659 · NIAAA · INLIGHTA BIOSCIENCES, LLC · PI YANG, JENNY J. · 2020 to 2021
$2.0M
Non-invasive staging of Metastasis by Precision MRIR44CA268403 · NCI · INLIGHTA BIOSCIENCES, LLC · PI XU, YITING · 2022 to 2023
$2.0M
Pre-clinical Validation of A Novel Protein Drug Candidate for ASH and NASH TreatmentR01DK126080 · NIDDK · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2021 to 2023
$1.8M
Targeted inhibition of ribosomal RNA synthesis in LKB1-deficient cancersR01CA203928 · NCI · EMORY UNIVERSITY · PI ZHOU, WEI · 2017 to 2021
$1.8M
Multi-color Mapping of Cancer Molecular Signatures and Tumor microenvironmentR33CA235319 · NCI · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2019 to 2021
$1.3M
Translational Research by 3T Molecular ImagingS10OD027045 · OD · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2019 to 2019
$600k
NCI NIH HHS P01 CA257906NCI NIH HHS P30 CA138292NCI NIH HHS R01 CA194027NCI NIH HHS R01 CA203928NCI NIH HHS R33 CA235319NCI NIH HHS R42 CA183376NCI NIH HHS R44 CA268403NIAAA NIH HHS R42 AA025863NIAAA NIH HHS UT2 AA028659NIBIB NIH HHS R01 EB007268NIDDK NIH HHS R01 DK126080NIH HHS S10 OD027045
6 · The paper itself

Abstract

Lung cancer with multiorgan metastasis remains the leading cause of cancer death. Current CT imaging and biopsy are suboptimal for detecting early tumors or subclinical metastases. We address this gap using LUAD with LKB1/STK11 inactivation, which alters collagen via focal adhesion kinase activation. Collagen I overexpression in the tumor microenvironment and invasive edge was identified as a biomarker. We developed hProCA32.Collagen, a protein MRI contrast agent targeting collagen I, which exhibits 10-fold higher relaxivity than clinical GBCAs, with strong Gd

Indexed as

CollagenContrast MediaEarly Detection of CancerLung NeoplasmsMagnetic Resonance ImagingAnimalsCell Line, TumorFemaleHumansMiceNeoplasm InvasivenessNeoplasm MetastasisCollagenContrast Media

Identifiers

PMID42715331
PMCPMC13557066

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.