Evidence map›Paper›PMID 42716015›Full record

ArticleNeuron2026

Neural geometry in the human hippocampus enables generalization across spatial position and gaze.

Assia Chericoni, Chad Diao, Xinyuan Yan, Taha S Ismail, Elizabeth A Mickiewicz, Melissa Franch, Ana G Chavez, Danika L Paulo, Vaishnav Krishnan, Mohamed Hegazy and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Assia ChericoniDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Chad DiaoDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Xinyuan YanDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Taha S IsmailDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Elizabeth A MickiewiczDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Melissa FranchDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Ana G ChavezDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Danika L PauloDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Vaishnav KrishnanDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Mohamed HegazyDepartment of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Alica M GoldmanDepartment of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Lu LinDepartment of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Gabriela Tantillo SepulvedaDepartment of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Garrett P BanksDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurosurgery, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
Nisha GiridharanDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Mohammed HasenDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Eleonora BartoliDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA.
Nicole R ProvenzaDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA; Department of Bioengineering, Rice University, Houston, TX 77005, USA; Neuroengineering Initiative, Rice University, Houston, TX 77005, USA.
Seng Bum Michael YooCenter for Neuroscience Imaging Research, Sungkyunkwan University, Suwon 16419, South Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, South Korea; Department of Intelligence Health Precision Convergence, Sungkyunkwan University, Suwon 16419, South Korea.
Jay HennigDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA; Neuroengineering Initiative, Rice University, Houston, TX 77005, USA.
Joshua JacobsDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA; Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA; Neuroengineering Initiative, Rice University, Houston, TX 77005, USA; Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories, Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Benjamin Y HaydenDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA; Neuroengineering Initiative, Rice University, Houston, TX 77005, USA. Electronic address: benhayden@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hippocampal neurons track the positions of self, others, and gaze direction. However, it is unclear how their respective neural codes differ enough to avoid confusion while allowing for abstraction across spatial frames. We recorded from populations of hippocampal neurons while human participants performed a joystick-controlled virtual prey-pursuit task. We found that neurons have mixed selective responses that map the positions of self, prey, and predator, as well as gaze direction. Their codes occupied mostly orthogonal subspaces, but the geometric structures of these subspaces allowed them to be aligned by simple linear transformations. Moreover, their geometries supported some degree of generalization, such that a linear rule learned on one agent could be transferred to another. This scheme enables reliable individuation and abstraction across both agent identity and viewpoint. Together, these findings suggest that hippocampal spatial knowledge is structured as a family of geometrically related manifolds that can be related through simple linear transformations.

Indexed as

gazehippocampushuman electrophysiologyneural geometryspatial navigationspatial view

Identifiers

PMID42716015

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.