Evidence map›Paper›PMID 42716381›Full record

ArticlePreventive medicine2026

Human behavioral pharmacology of cannabis: Insights on cannabis use disorder.

Margaret Haney, Caroline A Arout, Margaret F Bedillion

Abstract read
In one paragraph

Article in Preventive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Margaret HaneyNew York State Psychiatric Institute, New York, NY, USA; Columbia University Irving Medical Center, New York, New York, USA. Electronic address: mh235@cumc.columbia.edu.
Caroline A AroutNew York State Psychiatric Institute, New York, NY, USA; Columbia University Irving Medical Center, New York, New York, USA.
Margaret F BedillionNew York State Psychiatric Institute, New York, NY, USA; Columbia University Irving Medical Center, New York, New York, USA.

Funding

Marijuana Relapse: Influence of Tobacco Cessation and VareniclineR01DA031005 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HANEY, MARGARET · 2010 to 2022
$5.2M
Repeated Administration of Cannabis Varying in THC and CBD: Effects on Abuse Liability, Experimental Pain and Plasma EndocannabinoidsR01DA053332 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Caroline A Arout, MARGARET HANEY · 2022 to 2026
$2.0M
NIDA NIH HHS R01 DA031005NIDA NIH HHS R01 DA053332
6 · The paper itself

Abstract

objectiveCannabis policy, public perception, and consumption patterns have undergone enormous shifts, yet the scientific understanding of these changes has lagged. Our objective is to describe how human behavioral pharmacology studies provide a rigorous framework for modelling Cannabis Use Disorder (CUD) and for informing the development of treatment approaches.

methodsThis narrative review synthesizes insights from over 25 years of human laboratory research, highlighting how behavioral pharmacology, e.g., dose, placebo control, behavioral specificity, inform the development of evidence-based therapies and targeting the behavioral drivers of CUD.

resultsKey takeaways: (1) Cannabis potency is not Δ

conclusionsRigorous, placebo-controlled human laboratory studies of the behavioral effects of cannabis are essential to informing a quickly evolving field complicated by the complexity of cannabis as a plant with a myriad of active constituents, regulatory hurdles, and industry narrative.

Indexed as

AddictionDose-response relationshipDouble-blindDrug toleranceMarijuana smokingPlaceboSelf-administrationSubstance useWithdrawal

Identifiers

PMID42716381
PMCPMC13615520

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.