Evidence map›Paper›PMID 42716685›Full record

Observational studyBMJ open2026

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Myrna van den Bos, Wouter V Vogel, Maurice van Duijvenvoorde, Niels F M Kok, Arend G J Aalbers, Petur Snaebjornsson, Miangela M Lacle, Jeroen R J Willemse, Walter Kool, Jeroen J M A Hendrikx and 9 more

Abstract readObservational StudyComparative Study
In one paragraph

Observational study in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Myrna van den BosDepartment of Imaging and Oncology, Laboratory Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.ORCID http://orcid.org/0000-0002-9249-8461
Wouter V VogelDepartment of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, Netherlands.
Maurice van DuijvenvoordeDepartment of Epidemiology and Health Economic Evaluation, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Niels F M KokDepartment of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands.
Arend G J AalbersDepartment of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands.
Petur SnaebjornssonDepartment of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Miangela M LacleDepartment of Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Jeroen R J WillemseDepartment of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Walter KoolDepartment of Nuclear Medicine and Cyclotron Noordwest B.V, Noordwest Ziekenhuisgroep Alkmaar, Alkmaar, Noord-Holland, Netherlands.
Jeroen J M A HendrikxDepartment of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, Netherlands.
Ignace H J T de HinghDepartment of Surgery, Catharina Hospital, Eindhoven, Netherlands.
Wilhelmina M U van GrevensteinDepartment of Surgical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Djamila BoermaDepartment of Surgery, St Antonius Ziekenhuis, Nieuwegein, Netherlands.
Anya N MilneDepartment of Pathology, St Antonius Ziekenhuis, Nieuwegein, Netherlands.
Andor F van den HovenDepartment of Nuclear Medicine, St Antonius Ziekenhuis, Nieuwegein, Netherlands.
Sjoerd G EliasDepartment of Epidemiology and Health Economic Evaluation, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Marnix G E H LamDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Max J LahayeDepartment of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands o.kranenburg@umcutrecht.nl m.lahaye@nki.nl.
Onno KranenburgDepartment of Imaging and Oncology, Laboratory Translational Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands o.kranenburg@umcutrecht.nl m.lahaye@nki.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionColorectal cancer patients with peritoneal metastases have a very poor prognosis. A minority of these patients is eligible for curative cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). The peritoneal cancer index (PCI) is an important criterion to select patients for CRS-HIPEC. Due to challenges in peritoneal metastasis detection by imaging, the PCI is currently routinely assessed by invasive diagnostic laparoscopy in addition to CT and/or MRI. Yet, open-close procedures and early disease recurrence following CRS-HIPEC are common, indicating the need for better patient selection tools. Fibroblast activation protein (FAP)-targeted imaging has recently emerged as a promising strategy for visualising peritoneal disease. The aim of this study is to assess the potential value of FAP inhibitor positron emission tomography/CT (FAPI-PET/CT) as an alternative non-invasive tool for quantitative PCI assessment. METHODS AND ANALYSIS: ETHICS AND DISSEMINATION: This study is approved by the assigned Medical-Research-Ethics-Committee (METC NedMec) on 19-08-2024. All participants will provide written informed consent. Study results will be disseminated through (inter)national meetings and peer-reviewed publications. TRIAL REGISTRATION NUMBER: 2024-512301-16-01.

Indexed as

Colorectal NeoplasmsPeritoneal NeoplasmsPositron Emission Tomography Computed TomographyAdultAgedCytoreduction Surgical ProceduresEndopeptidasesFemaleFibroblast Activation Protein AlphaFluorine RadioisotopesGelatinasesHumansHyperthermic Intraperitoneal ChemotherapyMagnetic Resonance ImagingMaleMembrane ProteinsEndopeptidasesFibroblast Activation Protein AlphaFluorine RadioisotopesGelatinasesMembrane ProteinsSerine EndopeptidasesColorectal NeoplasmsCytoreduction Surgical ProceduresFibroblast Activation Protein AlphaNeoplasm StagingPeritoneal NeoplasmsPositron Emission Tomography Computed Tomography

Identifiers

PMID42716685
PMCPMC13560996

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.